Diffuse large b-cell lymphoma (DLBCL) is an aggressive and potentially curable lymphoma that presents itself as stage I-II in 30% of all cases. It is known that in these localized stages, 15-20% of patients treated without rituximab eventually relapse, but less data exist regarding rituximab era. We have analyzed clinico-pathological features and risk of relapse in 98 patients with I-II stage D...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Ca(2+) sparks arise from the stochastic opening of spatially discrete clusters of ryanodine receptors called a Ca(2+) release unit (CRU). If the RyR clusters were not spatially separated, then Ca(2+) released from one RyR would immediately diffuse to its neighbor and lead to uncontrolled, runaway Ca(2+) release throughout the cell. While physical separation provides some isolation from neighbor...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Varying, limiting numbers of unseparated or purified cells (Ly-5.1). either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with I O 5 unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). The kinetics of donor cell repopulation of the lymphoid and myeloid compartments by Ly-5.1’ donor hematopoietic stem cells (ie, competitiv...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

This report presents updated time-to-event variables from a multicenter phase II trial of reduced-dose 90Y ibritumomab tiuxetan in patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma (NHL) and mild thrombocytopenia (platelet counts of 100 to 149 x 10(9) platelets/L). Patients received a single course of ibritumomab tiuxetan radioimmunotherapy...

Patients with mantle cell lymphoma (MCL) generally respond to first-line immunochemotherapy, but often show chemoresistance upon subsequent relapses, with poor outcome. Several studies of the immunomodulator, lenalidomide, have demonstrated its activity in MCL including the MCL-001 study in relapsed/refractory patients who had failed defined prior therapies of anthracyclines or mitoxantrone, cy...

We have used optical interferometry to obtain multi-wavelength visibility curves for eight red giants over the wavelength range 650–1000 nm. The observations consist of wavelengthdispersed fringes recorded with MAPPIT (Masked APerture-Plane Interference Telescope) at the 3.9-m Anglo-Australian Telescope. We present results for four Miras (R Car, o Cet, R Hya, R Leo) and four semi-regular variab...

Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models. Cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were used to assess anti-ulcerogenic activity of KV in rats. Effects of KV on gastric juice for free and total acidity, peptic activity ...