TetraPEGylated canine Hb, [SP (succinimidophenyl)-PEG5K]4-canine-Hb, with PEGylation at its four reactive cysteine residues (a111 and b93) has been prepared and characterized. The hydrodynamic volume and the molecular radius of (SP-PEG5K)4-canine-Hb are intermediate to those of di- and hexaPEGylated human Hb as expected. However, the COP (colloidal osmotic pressure) of tetraPEGylated canine Hb ...

In the sickle cell syndromes, Hb A2 measurements aid in the differential diagnosis of sickle cell anemia from sickle-beta-thalassemia. The purpose of this study is to assess the Hb A2 levels in samples containing sickle hemoglobin (Hb S) by the use of an automated high performance liquid chromatography system (HPLC-Variant beta-thalassemia Short Program). The blood samples analyzed were from in...

Seven patients of Chinese origin who had haemoglobin (Hb) Q-H disease were studied. They were found to have a similar clinical phenotype to that of patients with deletional Hb H disease, who have a near identical genotypic configuration. The complete absence of Hb A in Hb Q-H disease and the similar clinical phenotype to deletional Hb H disease lends support to the observation that Hb Q-Thailan...

انتقال ویروس کرونا به داخل سلول از طریق اسپایک‌های انجام می‌شود پس یکی بهترین راه‌های مقابله با سلول‌های بدن، ایجاد اختلال در روند عملکرد است. بنابراین این تحقیق، چگونگی جذب و انرژی پرتوهای رادیواکتیو سارس کووید2، مرس کووید، یوکی کووید توسط ابزار جینت4- دی اِن اِی شبیه‌سازی شده نتایج حاصل پرتودهی اسپایک‌ها یکدیگر مقایسه آن‌جایی که عوامل کاهش ماندگاری می‌باشد، پژوهش سعی است اسپایک ویروس­‌ها به‌وسی...

By TITUS H. J. HuIS sL&rc AND RALPH C. LEE I N A PREVIOUS PAPER6 we reported the discovery of an abnormal minor hemoglobin in a Negro family ( Fam. S ) in Georgia. This hemoglobin, designated as Hb-Flatbush0 , showed the following properties : ( a ) an electrophoretic mobility ( starch gel electrophoresis at pH 8.1 ) intermediate between Hb-S and Hb-F; ( b ) a chromatographic mobility ( DEAE-ce...

By BENNETT F. HORTON, ROBERT B. THOMPSON, ANDREE M. Dozy, CARL M. NECHTMAN, EVAN NIcHOLs AND TITUS H. J. HUISMAN D URING the past few years, some human hemoglobins have been found composed of one single type of polypeptide chain in contrast to the more common hemoglobins, composed of two types of polypeptide chains. The most important of these are Hb-Bart’s, composed of four of the y chains of ...

Approximately 5.1% of the US population has diabetes mellitus, and hemoglobin (Hb) A1c levels are routinely measured to monitor long-term glycemic control in these patients. Many laboratories use ion exchange chromatography for such measurements, and the presence of hemoglobin variants and hemoglobinopathies often results in abnormal peaks on the chromatogram. The goal of this study was to eval...

background studies on the association between maternal hemoglobin (hb) concentration and adverse pregnancy outcome have been inconsistent. many studies have shown the impact of hb concentration on pregnancy outcomes in adult women; however, it is not revealed in adolescent pregnant women. objectives the aim of this study was to examine the effect of hb concentration on birth outcomes in pregnan...