gholamhossein hassanshahi immunology and hematology departments, medical school, rafsanjan university of medical sciences,
rafsanjan, iran mohammad kazemi arababadi immunology and hematology departments, medical school, rafsanjan university of medical sciences,
rafsanjan, iran alan james dickson biochemistry department, faculty of life sciences, manchester university, manchester, uk
background: it is now well established that several environmental stress factors cause activation of p38 map kinase and jnk in various cell types to produce chemokines. objective: to investigate the expression of cxc chemokines gro/kc and sdf- 1a in rat's h4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. methods: hepatoma cells were maintained in mem medium...
حدواسط کیتین ایمینی حاصل از واکنش افزایشی آسیل کلریدها ، ایزوسیانیدها و تری آلکیل فسفیت ها، با پارا-تولوئن سولفونیل متیل ایزوسیانید (توسمیک) واکنش می دهد و مشتق های پیرول را با بازده بالا بدست می دهد.
از واکنش بین محصول افزایشی آسیل کلریدها و ایزوسیانیدها، با فنیل هیدرازین و کربن دی سولفید در دمای اتاق، مشتق های تیازولیدین با بازده بالا بدست می آید.
مشتق های 2-پیرولین از واکنش محصول افز...
The four histones of the nucleosome core particle are all subject to enzyme-catalysed, post-translational acetylation at defined lysine residues in their amino-terminal domains. Much circumstantial evidence suggests a role for this process in modifying chromatin structure and function, but detailed mechanisms have not been defined. To facilitate studies on the functional significance of histone...
Ahmed FazlyQing LiQi HuGeorges MerBruce HorazdovskyZhiguo Zhang
Background: Rtt106 is a histone H3-H4 chaperone. Results: Rtt106 oligomerizes through its N terminus and binds (H3-H4)2 tetramers in vitro and in vivo. Conclusion: Rtt106 likely deposits (H3-H4)2 tetramers to promote nucleosome assembly. Significance:Determining the stoichiometry ofH3-H4molecules that associate with Rtt106will increase our understanding on how nucleosomes are formed during S ph...
Nomsa P. TauParastu MeidanyAnthony M. SmithArvinda SookaKaren H. Keddy
To determine the origin of >4,000 suspected diarrheagenic Escherichia coli strains isolated during 2004-2011 in South Africa, we identified 7 isolates as serotype O104; 5 as enteroaggregative E. coli O104:H4, and 2 as enteropathogenic E. coli O104:non-H4. Pulsed-field gel electrophoresis showed that these isolates were unrelated to the 2011 E. coli O104:H4 outbreak strain from Germany.
A real-time multiplex PCR targeting stx(2), wzy(O104), and fliC(H4) of enterohemorrhagic Escherichia coli (EHEC) O104:H4 correctly determined the presence or absence of these genes in 253 EHEC isolates and enrichment cultures of stool samples from 132 patients. It is a rapid, sensitive, and specific tool for detecting EHEC O104:H4 in human stools.
Tara ElvangJan P. ChristensenRolf BilleskovTruc Thi Kim Thanh HoangPeter HolstAllan Randrup ThomsenPeter AndersenJes Dietrich
BACKGROUND
Although CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consisting of both CD4 and CD8 T cells.
METHODS AND FINDINGS
To compare CD4 and CD8 responses against Ag85B-TB10.4 (H4), H4 ...
Previous studies indicated that B7-H4, the youngest B7 family, negatively regulates T cell-mediated immunity and is significantly overexpressed in many human tumors. Tumor stem cells are purported to play a role in tumor renewal and resistance to radiation and chemotherapy. However, the link between B7-H4 and tumor stem cells is unclear. In this study, we investigated B7-H4 expression in the me...
A közgazdaságtan a társadalom gazdasági folyamatait elemzi. Egy bevezetésben célszerű a részletek mellőzésével az egész közgazdaságtant áttekinteni. A közgazdaságtan magva a mikroökonómia, amely a fogyasztók és a vállalatok döntéseit adott gazdasági keretek mellett vizsgálja. Bemutatja, hogy a profitmaximalizáló vállalatok és a hasznosságmaximalizáló egyének összjátékából hogyan alakul ki a pia...
