HSCT from an unrelated HLA-mismatched donor (MMUD) is one of the alternatives where HLA-matched not found. The aim this study was to compare GvHD prophylaxis with anti-thymocyte globulin (ATG) vs. post-transplant cyclophosphamide (PT-Cy). Thirty-nine adult patients were uniformly treated rabbit ATG-Cy-A-MTX and peripheral blood stem cell (PBSC) 40 PT-Cy-MMF-tacrolimus PBSC. This retrospective r...

Background: When it comes to the treatment of aplastic anemia fever, Guidelines for Aplastic Anemia regards Anti-thymocyte globulin (ATG) combined with eltrombopag as standard immunosuppressive plan, and ATG is main mode treat severe anemia. A large number prospective studies clinical trials have confirmed application value in Although brings satisfactory results, safety long-term use still unc...

Antithymocyte globulin (ATG) and muromonab CD3 (OKT3) are currently the only antilymphocyte preparations that are commercially available for induction immunosuppressive therapy for renal allograft transplantation in the US. ATG, in the usually prescribed doses, is more expensive than muromonab CD3, but muromonab CD3 is associated with more severe adverse effects that may affect clinical outcome...

The accepted model of eukaryotic translation initiation begins with the scanning of the transcript by the pre-initiation complex from the 5'end until an ATG codon with a specific nucleotide (nt) context surrounding it is recognized (Kozak rule). According to this model, ATG codons upstream to the beginning of the ORF should affect translation. We perform for the first time, a genome-wide statis...

Humans have circulating antibodies against diverse glycans containing N-glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the CMAH gene. This xenogenic non-human carbohydrate is abundant in red meat, xenografts and biotherapeutics. Low levels of diet-derived Neu5Gc is also present on normal human endothelial cells, and together with anti-Neu5Gc antibodies could potentially media...

We present an automatic text generation system (ATG) developed for the generation of natural language text for automatically produced test items. This ATG has been developed to work with an automatic item generation system for analytical reasoning items for use in tests with high-stakes outcomes (such as college admissions decisions). As such, the development and implementation of this ATG is c...

Objective: The aim of this study was to investigate the success rate and effects on survival of different anti-thymocyte globulin (ATG) preparations in patients diagnosed with aplastic anemia. Subjects and Methods: Of the total 24 patients included in the study, 12 were male and 12 female with a median age of 44 years (range 16–72). Nine patients received Lymphoglobulin , 7 Thymoglobulin and AT...

BACKGROUND Costimulation blockade with antibodies directed against human CD40 and CD86 leads to prolonged kidney allograft survival in rhesus monkeys, but fails to induce permanent graft acceptance. We have tested whether costimulation blockade is more effective after peripheral T-cell ablation with antithymocyte globulin (ATG), with the aim to remove already primed autoreactive cells present i...

BACKGROUND The use of antilymphocyte agents has improved patient and graft survival in hematopoietic stem cell and solid organ transplantation but has been associated with the development of short-term toxicities as well as long-term complications. CASE PRESENTATION We report a young female with Fanconi anemia who received antithymocyte globulin as part of the conditioning regimen prior to he...