This paper presents a method based on the reciprocal root locus (RRL) approach for solving the multiple vehicle path coordination problem. A high level planning assigns the tasks to each vehicle, specifying each mission, inside a structured workspace with known obstacles. The problem is solved in two steps: first the given workspace is mapped onto a semicircle, using the theory of conformal map...

A novel stochastic adaptation of the recurrent reinforcement learning (RRL) methodology is applied to daily, weekly, and monthly stock index data, and compared to results obtained elsewhere using genetic programming (GP). The data sets used have been a considered a challenging test for algorithmic trading. It is demonstrated that RRL can reliably outperform buy-and-hold for the higher frequency...

Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subse...

PURPOSE Clarithromycin was considered the cornerstone for the treatment of Mycobacterium abscessus complex infections. Genetic resistance mechanisms have been described and many experts propose amikacin as an alternative. Nevertheless, clarithromycin has several advantages; therefore, it is necessary to identify the non-functional erm(41) allele to determine the most suitable treatment. The aim...

For a relational reinforcement learning (RRL) agent, learning a model of the world can be very helpful. However, in many situations learning a perfect model is not possible. Therefore, only probabilistic methods capable of taking uncertainty into account can be used to exploit the collected knowledge. It is clear then that RRL offers an interesting testbed for statistical relational learning me...

The virion host shutoff protein (vhs) of herpes simplex virus triggers accelerated degradation of cellular and viral mRNAs while sparing other cytoplasmic RNA species. Previous work has shown that vhs forms a complex with translation initiation factor eIF4H, which displays detectable RNase activity in the absence of other viral or host proteins. However, the contributions of eIF4H and other hos...