نتایج جستجو برای: اپی گالو کاتچین گالات egcg

تعداد نتایج: 4032  

2014
Wei Zhu Jing Xu Yangyang Ge Han Cao Xin Ge Judong Luo Jiao Xue Hongying Yang Shuyu Zhang Jianping Cao

Epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent of green tea, is a potent antioxidant and free radical scavenger that may have therapeutic applications for the treatment of many disorders. Radiation therapy is widely used for the treatment of various types of cancers; however, radiation-induced skin injury remains a serious concern. EGCG has not yet been reported as protec...

2017
Bin Yang Peng Gao Xuejun Wu Jixiang Yu Yu Li Ranran Meng Yubin Li Jingqiang Yan Xing Jin

Epigallocatechin-3-gallate (EGCG) is a kind of polyphenol compound, called catechin, and is extracted from green tea. EGCG has a wide range of biological activities. The present study aimed to evaluate the effect of EGCG on neointimal hyperplasia in a rat model of carotid artery balloon injury and to explore the molecular mechanisms involved. Various experiments were performed to assess the eff...

Journal: :Biophysical journal 2009
Yen Sun Wei-Chin Hung Fang-Yu Chen Chang-Chun Lee Huey W Huang

A major component of green tea extracts, catechin (-)-Epigallocatechin gallate (EGCg), has been reported to be biologically active and interacting with membranes. A recent study reported drastic effects of EGCg on giant unilamellar vesicles (GUVs). In particular, EGCg above 30 microM caused GUVs to burst. Here we investigated the effect of EGCg on single GUVs at lower concentrations, believing ...

Journal: :Cancer research 2008
Jichao Qin He-Ge Chen Qin Yan Mi Deng Jinping Liu Stephan Doerge Weiya Ma Zigang Dong Wan-Cheng David Li

(-)-Epigallocatechin-3-gallate (EGCG) is a well-known chemoprevention factor. Recent studies have revealed that EGCG triggers cancer cells undergoing apoptosis through p53-dependent pathway. How EGCG activates p53-dependent apoptosis is not fully understood. In the present study using JB6 cell as a model system, we have shown that EGCG can negatively regulate protein serine/threonine phosphatas...

2013
SONG YI PARK CHANG HEE JUNG BOKYUNG SONG OCK JIN PARK YOUNG-MIN KIM

The present study investigated the regulatory mechanisms by which epigallocatechin-3-gallate (EGCG) exerts vascular endothelial growth factor (VEGF)-, p53- and AMP-activated protein kinase (AMPK)-associated pro-apoptotic and migration-suppressing effects on colon cancer cells. EGCG decreased the expression levels of VEGF and matrix metalloproteinase (MMP)-9. EGCG treatment induced apoptosis in ...

2014
JUN-ICHIRO SONODA RYUJI IKEDA YASUTAKA BABA KEIKO NARUMI AKIO KAWACHI ERISA TOMISHIGE KAZUYA NISHIHARA YASUO TAKEDA KATSUSHI YAMADA KEIZO SATO TOSHIRO MOTOYA

Clinical and epidemiological studies have indicated that the consumption of green tea has a number of beneficial effects on health. Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, has received much attention as an active ingredient. Among the numerous promising profiles of EGCg, the present study focused on the anticancer effects. Apoptosis induced by EG...

Journal: :Acta medica 2014
Alena Moravcova Zuzana Cervinkova Otto Kucera Vojtech Mezera Halka Lotkova

Literature data support that green tea and its major component epigallocatechin gallate (EGCG) have powerful antioxidant effects. Contrary, hepatotoxicity can be induced by high-dose EGCG. The timing of exposure to green tea in relation to administration of hepatotoxic agent plays an import role too. The aim of our work was a verification of antioxidative effect of EGCG on D-galactosamine-induc...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Debora Porath Christoph Riegger Juergen Drewe Joseph Schwager

A major component in green tea, epigallocatechin-3-gallate (EGCG), is reported to interfere with different steps of a number of inflammatory pathways. After oral administration, EGCG is retained in the gastrointestinal tract, where it is thought to exert preventive functions against inflammatory bowel disease and colon cancer. In this study, the human colon adenocarcinoma cell lines HT29 and T8...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Tetsuya Yamamoto Stephen Hsu Jill Lewis John Wataha Douglas Dickinson Baldev Singh Wendy B Bollag Petra Lockwood Eisaku Ueta Tokio Osaki George Schuster

Green tea polyphenols (GTPPs) are considered beneficial to human health, especially as chemopreventive agents. Recently, cytotoxic reactive oxygen species (ROS) were identified in tumor and certain normal cell cultures incubated with high concentrations of the most abundant GTPP, (-)-epigallocatechin-3-gallate (EGCG). If EGCG also provokes the production of ROS in normal epithelial cells, it ma...

Journal: :Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006
R A Isbrucker J A Edwards E Wolz A Davidovich J Bausch

Green tea extract and its principal active ingredient, epigallocatechin gallate (EGCG), are gaining attention and increased usage due to their healthful properties. Despite the increasing demand for these products, few studies have examined their safety. The toxicity of purified green tea extracts containing high concentrations of EGCG have been evaluated in a series of studies in order to defi...

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