Suppression of protein kinase A regulatory subunit 1 alpha (PRKAR1A) has been proven to inhibit cholangiocarcinoma (CCA) cell growth and enhance apoptosis. In the present study, we aimed to determine synergistic and/or additive effects of chemotherapeutic agents, including protein kinase inhibitors (i.e. sorafenib, sunitinib, gefitinib, Met inhibitor) and conventional chemotherapeutic drugs (i....

We address the problem of integrating textual and visual information in vector space models for word meaning representation. We first present the Residual CCA (R-CCA) method, that complements the standard CCA method by representing, for each modality, the difference between the original signal and the signal projected to the shared, max correlation, space. We then show that constructing visual ...

The Common Component Architecture (CCA) specification is designed to provide a plug-and-play environment for scientists to manage the complexity of large-scale scientific simulations. The same specification is used for the implementation of sequential, parallel and distributed frameworks. The CCA specification places minimal requirements on the framework design, thus allowing various research g...

Hotelling’s Canonical Correlation Analysis (CCA) works with two sets of related variables, also called views, and its goal is to find their linear projections with maximal mutual correlation. CCA is most suitable for unsupervised feature extraction when given two views but it has been also long known that in supervised learning when there is only a single view of data given, the supervision sig...

CCA is a powerful tool for analyzing paired multi-view data. However, when facing semi-paired multi-view data which widely exist in real-world problems, CCA usually performs poorly due to its requirement of data pairing between different views in nature. To cope with this problem, we propose a semi-paired variant of CCA named SemiPCCA based on the probabilistic model for CCA. Experiments with a...

Mutation of the Arabidopsis thaliana tRNA (Trp)(CCA) anticodon or of the A73 discriminator base greatly diminishes in vitro aminoacylation with tryptophan, indicating the importance of these nucleotides for recognition by the plant tryptophanyl-tRNA synthetase. Mutation of the tRNA (Trp)(CCA) anticodon to CUA so as to translate amber nonsense codons permits tRNA (Trp)(CCA) to be aminoacylated b...

Changes in protein glycosylation have been reported in various types of cancer, including cholangiocarcinoma (CCA). Nanospray ionization-linear ion trap mass spectrometry (NSI-MS n ) was used in the present study to determine the comparative structural glycomics of the N-linked glycans in the serum of patients with CCA compared with healthy controls. A total of 5 high-mannose and 4 complex N-li...

A novel Cellular Automata (CA)  Controllable CA (CCA) is proposed in this paper. Further, CCA are applied in Pseudorandom Number Generation. Randomness test results on CCA Pseudorandom Number Generators (PRNGs) show that they are better than 1-d CA PRNGs and can be comparable to 2-d ones. But they do not lose the structure simplicity of 1-d CA. Further, we develop several different types of CC...

Steady-state visual evoked potential (SSVEP)-based brain computer-interface (BCI) is one of the most popular BCI systems. An efficient SSVEP-based BCI system in shorter time with higher accuracy in recognizing SSVEP has been pursued by many studies. This paper introduces a novel multiway canonical correlation analysis (Multiway CCA) approach to recognize SSVEP. This approach is based on tensor ...