نتایج جستجو برای: اهمیت نسبی siv

تعداد نتایج: 117381  

Journal: :Journal of virology 2008
Ronald S Veazey Paula M Acierno Kimberly J McEvers Susanne H C Baumeister Gabriel J Foster Melisa D Rett Michael H Newberg Marcelo J Kuroda Kenneth Williams Eun-Young Kim Steven M Wolinsky E Peter Rieber Michael Piatak Jeffrey D Lifson David C Montefiori Charles R Brown Vanessa M Hirsch Jörn E Schmitz

Previously we have shown that CD8(+) T cells are critical for containment of simian immunodeficiency virus (SIV) viremia and that rapid and profound depletion of CD4(+) T cells occurs in the intestinal tract of acutely infected macaques. To determine the impact of SIV-specific CD8(+) T-cell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) lymphocyt...

Journal: :PLoS Pathogens 2008
Robert De Rose Caroline S. Fernandez Miranda Z. Smith C. Jane Batten Sheilajen Alcântara Vivienne Peut Erik Rollman Liyen Loh Rosemarie D. Mason Kim Wilson Matthew G. Law Amanda J. Handley Stephen J. Kent

Effective immunotherapies for HIV are needed. Drug therapies are life-long with significant toxicities. Dendritic-cell based immunotherapy approaches are promising but impractical for widespread use. A simple immunotherapy, reinfusing fresh autologous blood cells exposed to overlapping SIV peptides for 1 hour ex vivo, was assessed for the control of SIV(mac251) replication in 36 pigtail macaque...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Salvador Huitron-Resendiz Maria Cecilia G Marcondes Claudia T Flynn Caroline M S Lanigan Howard S Fox

In monkeys infected with simian immunodeficiency virus (SIV), changes in body temperature and locomotor activity occur after the acute retroviral syndrome stage of the disease. However, alterations to the circadian rhythm of these factors in SIV-infected monkeys have not been reported. To determine whether the circadian rhythm of body temperature and locomotor activity are disrupted during SIV ...

2016
Hiroshi Ishii Saori Matsuoka Takushi Nomura Midori Nakamura Teiichiro Shiino Yuko Sato Naoko Iwata-Yoshikawa Hideki Hasegawa Kazuta Mizuta Hiromi Sakawaki Tomoyuki Miura Yoshio Koyanagi Taeko K. Naruse Akinori Kimura Tetsuro Matano

Virus-specific CD8(+) T cells exert strong suppressive pressure on human/simian immunodeficiency virus (HIV/SIV) replication. These responses have been intensively examined in peripheral blood mononuclear cells (PBMCs) but not fully analyzed in lymph nodes (LNs), where interaction between CD8(+) T cells and HIV/SIV-infected cells occurs. Here, we investigated target antigen specificity of CD8(+...

Journal: :Journal of virology 2011
Nana F Bello Fan Wu Paola Sette Vincent Dussupt Vanessa M Hirsch Fadila Bouamr

In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional determinant. Mutation of distal leucines (499)L and (502)L (LL mutant) caused...

Journal: :Journal of virology 2008
Elisa I Choi Keith A Reimann Norman L Letvin

The contribution of natural killer (NK) cells to the immune containment of human immunodeficiency virus infection remains undefined. To directly assess the role of NK cells in an AIDS animal model, we depleted rhesus monkeys of >88% of CD3(-) CD16(+) CD159a(+) NK cells at the time of primary simian immunodeficiency virus (SIV) infection by using anti-CD16 antibody. During the first 11 days foll...

Journal: :Science 1992
M D Daniel F Kirchhoff S C Czajak P K Sehgal R C Desrosiers

Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the persistent, unrelenting nature of HIV and SIV infection once infection is initiated. SIV with a constructed deletion in the auxiliary gene nef replicates poorly in rhesus monkeys and a...

Journal: :Journal of virology 2013
Monica Vaccari Brandon F Keele Steven E Bosinger Melvin N Doster Zhong-Min Ma Justin Pollara Anna Hryniewicz Guido Ferrari Yongjun Guan Donald N Forthal David Venzon Claudio Fenizia Tia Morgan David Montefiori Jeffrey D Lifson Chris J Miller Guido Silvestri Margherita Rosati Barbara K Felber George N Pavlakis James Tartaglia Genoveffa Franchini

We used the simian immunodeficiency virus mac251 (SIV(mac251)) macaque model to study the effect of the dose of mucosal exposure on vaccine efficacy. We immunized macaques with a DNA prime followed by SIV gp120 protein immunization with ALVAC-SIV and gp120 in alum, and we challenged them with SIV(mac251) at either a single high dose or at two repeated low-dose exposures to a 10-fold-lower dose....

Journal: :Journal of immunology 2014
Mahesh Mohan Lawrance C Chandra Workineh Torben Pyone P Aye Xavier Alvarez Andrew A Lackner

HIV replication and the cellular micro-RNA (miRNA) machinery interconnect at several posttranscriptional levels. To understand their regulatory role in the intestine, a major site of HIV/SIV replication, dissemination, and CD4(+) T cell depletion, we profiled miRNA expression in colon following SIV infection (10 acute SIV, 5 uninfected). Nine (four up and five down) miRNAs showed statistically ...

Journal: :Blood 1997
M Rosenzweig D F Marks D Hempel M Heusch G Kraus F Wong-Staal R P Johnson

Evaluation of candidate genes for stem cell gene therapy for acquired immunodeficiency syndrome (AIDS) has been limited by the difficulty of supporting in vitro T-cell differentiation of genetically modified hematopoietic progenitor cells. Using a novel thymic stromal culture technique, we evaluated the ability of a hairpin ribozyme specific for simian immunodeficiency virus (SIV) and human imm...

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