Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret activation promotes ENS precursor survival, proliferation, and migration and provides trophic support for mature enteric neurons. Although these roles are well established, we now provide evidence that increasing levels of the Ret ligand glial cell line-derived neurotrophic factor (GDNF) in mice causes alter...

Acquired or congenital disruption in enteric nervous system (ENS) development or function can lead to significant mechanical dysmotility. ENS restoration through cellular transplantation may provide a cure for enteric neuropathies. We have previously generated human pluripotent stem cell (hPSC)-derived tissue-engineered small intestine (TESI) from human intestinal organoids (HIOs). However, HIO...

OBJECTIVES To detail empty nose syndrome (ENS), an iatrogenic disorder characterized by a patent airway but a subjective sense of poor nasal breathing, and to explore repair options for patients with ENS. DESIGN A case series of 8 patients with ENS detailing symptoms before and after submucosal implantation of acellular dermis. SETTING Academic medical center. PATIENTS Subjects who were e...

The enteric nervous system (ENS) is a complex network of neurons and glia within the gut wall which originate from neural crest cells. Self-renewing, multipotential ENS progenitors have been isolated from the gut of foetal as well as adult rodents, however, the identity of the ENS progenitor and the regulation of its neurogenic potential invivo, are currently unknown. Sox10 is an HMG-containing...

The enteric nervous system (ENS) in mammals is derived from a small pool of progenitor cells, namely enteric neural crest cells (NCCs). These precursor cells proliferate extensively to expand, migrate over a long distance to fully colonize the developing gut and differentiate into millions of neurons and glia to form a functional ENS for regulating the complex behaviors of the gut. This develop...

The OKKAM project aims at enabling the Web of Entities, a global digital space for publishing and managing information about entities. The project provides a scalable and sustainable infrastructure, called the Entity Name System (ENS), for the systematic reuse of global and unique entity identifiers. The ENS provides a collection of core services supporting entity identifiers pervasive reuse. T...

BACKGROUND To determine the impact of a radiology electronic notification system (ENS) on emergency department (ED) patient care. MATERIALS AND METHODS A retrospective review of de-identified patient data for a 2-year period (1 year prior to and 1 year following ENS implementation) was approved by the hospital's institutional review board. The effect of a radiology ENS on ED patient care was ...

Complex circuits involving both local intrinsic neurones (i.e. enteric nervous system; ENS) and extrinsic neurones achieve nervous control of digestive functions. The ENS is comprised of many functionally different types of neurons: sensory neurons, interneurons and secreto-motor neurons. Each neuronal population is required to manifest local reflex behavior and is central to the regulation of ...

Malta Medical Journal Volume 25 Issue 03 2013 Introduction Empty Nose Syndrome (ENS) is a term first introduced by Kern and Moore which is used to describe a rare spectrum of various symptoms suffered by patients who had had previous radical turbinate surgery with a CT scan appearance of the paranasal sinuses after gross tissue loss. The most common symptom is socalled ‘‘paradoxical’’ nasal obs...