AIMS Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and its incremental value when used with computed tomography coronary angiography (...

BACKGROUND/AIM Majority of patients with hepatocellular carcinoma (HCC) belonged to Child-Turcotte-Pugh (CTP) class A. We aimed to identify a new class of patients with very well-preserved liver function and analyze its impact on outcome prediction, tumor staging and treatment allocation. METHODS A total of 2654 HCC patients were retrospectively analyzed. The prognostic ability was compared b...

BACKGROUND Accumulation of the cytosine arabinoside (ara-C) metabolite ara-C-triphosphate (ara-CTP) in leukemic blast cells is considered to be the main determinant of ara-C cytotoxicity in vitro and in vivo. Retinoids such as all-trans-retinoic acid (ATRA) have been shown to increase the sensitivity of acute myelogenous leukemic (AML) blast cells to ara-C. To investigate the mechanism of this ...

Introduction: In Canada, the Access to Cannabis for Medical Purposes Regulations (ACMPR) has given nurse practitioners (NPs) the power to authorize cannabis for therapeutic purposes (CTP) to eligible patients. This expansion in NPs' scope of practice underscores the importance of delivering balanced, evidence-based education on cannabis to NPs. The aim of this national study was to assess NPs' ...

BACKGROUND Coronary computed tomography angiography (CTA) enables accurate anatomic evaluation of coronary artery stenosis but lacks information about hemodynamic significance. The aim of this study was to evaluate 128-slice myocardial CT perfusion (CTP) imaging with adenosine stress using a high-pitch mode, in comparison with cardiac MRI (CMR). METHODS AND RESULTS Thirty-nine patients with i...

BACKGROUND AND PURPOSE The semiquantitative noncontrast CT Alberta Stroke Program Early CT Score (ASPECTS) and RAPID automated computed tomography (CT) perfusion (CTP) ischemic core volumetric measurements have been used to quantify infarct extent. We aim to determine the correlation between ASPECTS and CTP ischemic core, evaluate the variability of core volumes within ASPECTS strata, and asses...

با توجه به تغییرات گسترده، مداوم و روزافزون در بازارهای جهانی تقاضای مشتریان، به‌کارگیری ابزارهایی قدرتمند قابل‌اطمینان برای پشتیبانی از تصمیم‌گیرندگان، اجتناب‌ناپذیر است. این منظور پژوهش حاضر، مسئله برنامه‌ریزی تولید شرایط احتمالی یک سیستم تولیدی هیبرید MTS/MTO بررسی شده رویکرد، مدل ارائه‌شده را به‌طور کامل MTO یا MTS نیز سازگار کرده به‌طورمعمول بازه میان‌مدت صورت گرفته است تصمیمات اخذشده هر م...

PURPOSE Patients leaving the hospital are at increased risk of functional decline and hospital readmission. The Employee and Community Health service at Mayo Clinic in Rochester developed a care transition program (CTP) to provide home-based care services for medically complex patients. The study objective was to determine the relationship between CTP use, 30-day hospital readmission, and Emerg...

Previous studies have indicated that deoxycytidine kinase (dCK) is requisite and rate limiting in the phosphorylation of 1-0-D-arabinofuranosylcytosine (ara-C) and 9-/8-D-arabinofuranosyl-2-fluoroadenine (Fara-A) on the pathway to their respective cytotoxic 5'-triphosphates. In K562 cells, the rate of triphosphate accumulation was maximal during incubation with 10 //M ara-C (35 ¿(M/h) and 300 ...