In drug discovery, machine learning is widely used to classify molecules as active or inactive against a particular target. The vast majority of these methods (supervised learning) needs a training set of objects (molecules) to develop a decision rule that can be used to classify new entities (the test set) into one of the two mentioned classes [1]. A lot of studies, searching an optimal learni...

Hotspot residues are important in the determination of protein-protein interactions, and they always perform specific functions in biological processes. The determination of hotspot residues is by the commonly-used method of alanine scanning mutagenesis experiments, which is always costly and time consuming. To address this issue, computational methods have been developed. Most of them are stru...

In software engineering community, defect prediction is one the active domain. For software’s success, it essential to reduce and data-mining gap. Software defects forecasts source code errors before testing phase. Methods for predicting defects, such as clustering, statistical methods, mixed algorithms, metrics based on neural networks, black box testing, white machine learning are frequently ...

Diabetes is a lifelong chronic disease defined by disorders in protein, fat and carbohydrate metabolism as result of complete or partial deficiency insulin hormone secreted from the pancreas. This caused absence body. Normal also breaks down intestines to convert nutrients into glucose. Then, when this glucose passes through blood, level sugar blood rises. In healthy people, transported cells w...

The effect of different cultivation methods on the content ganoderic acids 7 species, 10 strains Ganoderma genus (Ganoderma applanatum 1899; сarnosum 2502; lucidum 1904; resinaceum 2477, 2503; sinense 2516; tsugae 1848, 2024, 2566, oregonense 2560) fungi from IBK Mushroom Culture Collection M.G. Kholodny Institute Botany National Academy Sciences Ukraine was investigated. It has been shown that...

<p><span>A Botnet is one of many attacks that can execute malicious tasks and develop continuously. Therefore, current research introduces a comparison framework, called BotDetectorFW, with classification complexity improvements for the detection attack using CICIDS2017 dataset. It free online dataset consist several high-dimensions features. The process feature selection significan...

Test suite code coverage is often used as an indicator for test capability in detecting faults. However, earlier studies that have explored the correlation between and effectiveness not addressed this evolutionally. Moreover, some of these works only small sized systems, or systems from same domain, which makes result generalization process unclear other domain systems. Software refactoring pro...

Meta decision trees (MDTs) are a method for combining multiple classifiers. We present an integration of the algorithm MLC4.5 for learning MDTs into the Weka data mining suite. We compare classifier ensembles combined with MDTs to bagged and boosted decision trees, and to classifier ensembles combined with other methods: voting and stacking with three different meta-level classifiers (ordinary ...