Formation of the C. elegans dauer larva is repressed by the chemosensory neurons ADF, ASI, and ASG. Mutant analysis has defined two parallel genetic pathways that control dauer formation. By killing neurons in these mutants, we show that mutations in one of these genetic pathways disrupt dauer repression by ADF, ASI, and ASG. One gene in this pathway is daf-7, which encodes a TGFbeta-related pr...

Precise oxygen equilibrium curves of human adult hemoglobin were determined by the automatic recording method at several temperatures in the presence and absence of 2,3diphosphoglycerate (DPG) or inositol hexaphosphate (IHP) with 0.05 M 2,2-bis(hydroxymethyl)-2,2’,2”nitrolotriethanol (bis-tris) buffers (pH 7.4) containing 0.1 M Cl-. The equilibrium data were analyzed according to the Adair sche...

The Notch pathway is dysregulated and a potential target in glioblastoma multiforme (GBM). Currently available Notch inhibitors block γ-secretase, which is necessary for Notch processing. However, Notch is first cleaved by α-secretase outside the plasma membrane, via a disintegrin and metalloproteinase-10 and -17. In this work, we used a potent α-secretase inhibitor (ASI) to test inhibition of ...

Interest in documenting ways to predict anxious responding in panic disorder (PD) patients has proliferated recently in the literature. In the current study, two self-report measures were assessed to determine their relative utility in predicting responses to a panicogenic challenge. The Anxiety Sensitivity Index (ASI) and the Suffocation Fear Scale (SFS) were evaluated by correlating scores on...

BACKGROUND Arterial stiffness is a physiologic quantitative value used to measure arterial compliance. It is predictive of coronary atherosclerosis in patients with intermediate to high cardiovascular risk. However, a correlation between arterial stiffness and subclinical coronary atherosclerosis has yet to be established. Therefore, the purpose of this study was to evaluate arterial stiffness ...

BACKGROUND We aimed to assess the relation of fractional pulse pressure (PPf) to aortic stiffness index and their impact on coronary flow reserve (CFR) and left ventricular diastolic function in asymptomatic diabetic patients. METHODS One hundred and thirty five consecutive asymptomatic diabetic patients (aged 48.8 ± 7.84 years), were included. CFR was calculated noninvasively using transthor...

Sociologists have begun to explore the gains for theory and research that might be achieved by artificial intelligence technology: symbolic processors, expert systems, neural networks, genetic algorithms and classifier systems. The first major accomplishments of artificial social intelligence (ASI) have been in the realm of theory, where these techniques have inspired new theories as well as he...

PURPOSE The National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO) is a scientific, comprehensive risk management program for scheduled therapeutics. NAVIPPRO provides post-marketing surveillance, signal detection, signal verification and prevention and intervention programs. Here we focus on one component of NAVIPPRO surveillance, the Addiction Severity Index-Multimedia V...

Recent progress in sea ice concentration remote sensing by satellite microwave radiometers has been stimulated by two developments: First, the new sensor AMSR-E offers spatial resolutions of approximately 6x4 km at 89 GHz, nearly three times the resolution of the standard sensor SSM/I at 85 GHz (15x13 km). Second, a new algorithm enables to estimate sea ice concentration from the channels near ...

Future gravitational wave detectors (GWDs) such as Advanced LIGO upgrades and the Einstein Telescope are planned to operate at cryogenic temperatures using crystalline silicon (cSi) test-mass mirrors at an operation wavelength of 1550 nm. The reduction in temperature in principle provides a direct reduction in coating thermal noise, but the presently used coating stacks which are composed of si...