Angiotensin-converting enzyme (ACE) inhibitors elicit outside-in signaling via ACE in endothelial cells. This involves the CK2-mediated phosphorylation of ACE on Ser1270 and the activation of the c-Jun N-terminal kinase (JNK)/c-Jun pathway, resulting in an enhanced endothelial ACE expression. Because cyclooxygenase-2 (COX-2) expression is reported to be increased in subjects treated with ACE in...

We describe ongoing work on a bidirectional mapping between Attempto Controlled English (ACE) and OWL DL. ACE is a well-studied controlled natural language, with a parser that converts ACE texts into Discourse Representation Structures (DRS). We show how ACE can be translated into OWL DL (by using the DRS as interlingua) and how OWL DL can be verbalized in ACE. This mapping renders ACE an inter...

The deletion (D)/insertion (I) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene has the greatest impact on serum ACE level in Caucasians of any factor yet discovered. The aim of the present study was to establish new ACE genotype-corrected normal ranges for serum ACE level in a population of central European origin. After a medical examination, 159 healthy Caucasians vo...

Portada del número 52 de la Revista ACE. Cover issue of ACE Journal.

Angiotensin converting enzyme (ACE) catalyses the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). The ACE activity directly related to hypertension as Ang II is the blood pressure regulating hormone. Therefore, ACE inhibitors are a major class of antihypertensive drugs. Captopril, chemical name, was the first orally active ACE inhibitory antihypertensive drug, discovered in 1977...

Background: Angiotensin converting enzyme (ACE) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin II that is a vasoconstrictor and mitogen factor. To date, the role of angiotensin II on regulating blood flow in inflamed joints has not been studied. Methods: Acute and chronic joint inflammation was induced in rabbits by intra-articular...

Previous studies have shown that induction of 2kidney -1clip Goldblatt hypertension (2K-1C) induction in rats eliminates hypertensive response after inactivating of the central nucleus of the amygdale (ACe). The present study investigated the possibility of alteration in local renin angiotensin system (RAS) activity in ACe after hypertension induction. Clamps were placed on the left renal arter...

We describe the architecture of a novel ontology and rule editor ACE View. The goal of ACE View is to simplify viewing and editing expressive and syntactically complex OWL/SWRL knowledge bases by making most of the interaction with the knowledge base happen via Attempto Controlled English (ACE). This makes ACE View radically different from current OWL/SWRL editors which are based on formal logi...