esmaeil mortaz department of immunology, medical school, shahid beheshti university of medical sciences, tehran, iran and chronic respiratory diseases research center and national research institute of tuberculosis and lung diseases (nritld), department of immunology, shahid beheshti university of medical sciences, tehran, iran and airways disease section, national heart and lung institute, imperial college london, london, uk fatemeh rezayat department of immunology, medical school, shahid beheshti university of medical sciences, tehran, iran davar amani department of immunology, medical school, shahid beheshti university of medical sciences, tehran, iran arda kiani chronic respiratory diseases research center and national research institute of tuberculosis and lung diseases (nritld), department of immunology, shahid beheshti university of medical sciences, tehran, iran johan garssen division of pharmacology, utrecht institute for pharmaceutical sciences, faculty of science, utrecht university, utrecht, the netherlands ian m. adcock airways disease section, national heart and lung institute, imperial college london, london, uk