Mussels are effective bioindicator organisms for aquatic environments. Therefore, they were often used to determine the effects of various xenobiotics in systems. There is no study our knowledge on vivo nanoparticles (NPs) activities ATPases freshwater mussels (Unio tigridis). This work demonstrates Al$_{2}$O$_{3}$, CuO, and TiO$_{2}$ NPs Na- ATPase, Ca-ATPase, Mg-ATPase gill muscle following 1...

The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in vitro. To investigate the structural basis for the promiscuous nature of this protein module, we have determined its solution structure by NMR in a complex with a peptide containing an NMSF sequence der...

The electronic structure and the spectroscopic constants of the low lying electronic states of the NaK ionic molecule have been determined through using an ab initio approach involving a non-empirical pseudopotential for the Na and K cores and core valence correlation correction. The potential energy of nearly 26 electronic states of R, P, and D symmetries has been calculated up to their dissoc...

We have studied the effect of 3,5,3 't r i iodothyronine (Ts) on the respiration of adul t rat hepatocytes in pr imary monolayer culture p repared f rom hypothyroid rat liver. After addit ion of T3 to the culture medium at a concentration of 2 x 10 -7 M, oxygen consumption of the cultured cells increased detectably at 24 h and was maximal at 72-96 h, relative to control cultures (38.0 -+ 1.8 vs...

This paper describes the design of a reliable multicast framework which integrates FEC and receiverinitiated retransmit to ensure reliability. A dynamically elected control tree is used to aggregate the NAKs and tackle the NAK implosion problem. Both techniques support flow and congestion control to enable efficient, high data rate multicast data transfer as performance measurements with our pr...

We investigate the scalability of feedback in multicast communication and propose a new method of probabilistic feedback based on exponentially distributed timers. By analysis and simulation for up to 106 receivers we show that feedback implosion is avoided with good latency performance obtained. The mechanism is robust against the loss of feedback messages and robust against homogeneous and he...

Potassium channels selectively conduct K(+), primarily to the exclusion of Na(+), despite the fact that both ions can bind within the selectivity filter. Here we perform crystallographic titration and single-channel electrophysiology to examine the competition of Na(+) and K(+) binding within the filter of two NaK channel mutants; one is the potassium-selective NaK2K mutant and the other is the...

In proximal tubular cells ischemia is known to result in the redistribution of apical and basolateral domain-specific lipids and proteins into the alternate surface membrane domain. Since tight junctions are required for the maintenance of surface membrane polarity, the effect of ischemia on tight junction functional integrity was investigated. In vivo microperfusion of early loops of proximal ...