BACKGROUND The purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial that required on-going RT QA review in the JCOG. METHODS JCOG 0202 was a multi-center phase III trial comparing two types of consolidation chemotherapy after concurrent chemoradiotherapy for limited-disease small ce...

During C. elegans development, LIN-12 (Notch) signaling specifies the anchor cell (AC) and ventral uterine precursor cell (VU) fates from two equivalent pre-AC/pre-VU cells in the hermaphrodite gonad. Once specified, the AC induces patterned proliferation of vulva via expression of LIN-3 (EGF) and then invades into the vulval epithelium. Although these cellular processes are essential for the p...

For more than a century, the déjà vu experience has been examined through retrospective surveys, prospective surveys, and case studies. About 60% of the population has experienced déjà vu, and its frequency decreases with age. Déjà vu appears to be associated with stress and fatigue, and it shows a positive relationship with socioeconomic level and education. Scientific explanations of déjà vu ...

This experiment aimed to create a laboratory analogue of déjà vu. During hypnosis, 1 group of high hypnotizables completed a puzzle game and then received a posthypnotic amnesia suggestion to forget the game (PHA condition). Another group of highs were not given the game but received a posthypnotic familiarity suggestion that it would feel familiar (PHF condition). After hypnosis, all participa...

1 cells by activating calpain 1 2 Cansu Yıldırım, Julie Favre, Ester M. Weijers, Ruud D. Fontijn, Michiel H. van Wijhe, 3 Sandra J. van Vliet, Reinier A. Boon, Pieter Koolwijk, Tineke C.T.M. van der Pouw Kraan 4 and Anton J.G. Horrevoets 5 Author Affiliations 6 1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 7 Amsterdam, The Netherlands. 8 2 Department of Ph...

Gerdien E. de Kloe, Jeroen Kool, Rene van Elk, Jacqueline E. van Muijlwijk-Koezen, August B. Smit, Henk Lingeman, Hubertus Irth, Wilfried M.A. Niessen and Iwan J.P. de Esch Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands, Leiden/Amsterdam Center for Drug Resear...