AIMS To assess the effects of renal impairment (RI) on the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus (T2DM). METHODS A cohort of Japanese patients with T2DM and mild to moderate RI and poor glycaemic control, despite diet/exercise therapy alone or diet/exercise therapy in combination with an oral hypoglycaemic agent (an α-glucosidase inhibitor, a sulfonylu...

BACKGROUND AND PURPOSE Patients with renal impairment (RI) have an increased risk of both thrombotic and hemorrhagic events. We aimed to clarify whether RI increases the risk of intracerebral hemorrhage (ICH) after intravenous thrombolysis with recombinant tissue plasminogen activator. METHODS Patients who received intravenous thrombolysis with recombinant tissue plasminogen activator within ...

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Journal Subject Codes: [3] Acute coronary syndromes [29] Coronary imaging [150] Imaging ngin in n n n n nee ee ee ee ee ee eeri ri ri ri ri ri ring ng ng ng ng ng ng a a a a a a and nd nd nd nd nd nd C C C C C C C Abstract Background—Recent reports show that plaque erosion can be diagnosed in vivo using optical

The severity of a tropical cyclone (TC) is often summarized by its lifetime maximum intensity (LMI), and the climatological LMI distribution is a fundamental feature of the climate system. The distinctive bimodality of the LMI distribution means that major storms (LMI >96 kt) are not very rare compared with less intense storms. Rapid intensification (RI) is the dramatic strengthening of a TC in...

Research infrastructure (RI) refers to a large and complex science research facility or system that conducts top-level science activities. In recent years, there has been a tendency toward geographical concentration of RIs and formation of RI clusters. Some of these RI clusters have become engines for regional social and economic development. It turns out that RI clusters present a new stage fo...

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