نتایج جستجو برای: α1 antitrypsin a1at
تعداد نتایج: 9172 فیلتر نتایج به سال:
inducing a proteolytic burden in the lung microenvironment. Under normal circumstances, A1AT and other antiproteases neutralize this threat posed by neutrophils. However, in A1AT deficiency, defenses are perturbed, leading to elastic degradation on lung tissue resulting in emphysema. While most COPD patients do not have A1AT, this genetic syndrome serves as a useful human model of how disturban...
The goal of this pilot study was to determine whether HDL glycoprotein composition affects HDL's immunomodulatory function. HDL were purified from healthy controls (n = 13), subjects with metabolic syndrome (MetS) (n = 13), and diabetic hemodialysis (HD) patients (n = 24). Concentrations of HDL-bound serum amyloid A (SAA), lipopolysaccharide binding protein (LBP), apolipoprotein A-I (ApoA-I), a...
BACKGROUND Alpha 1 antitrypsin (A1AT) deficiency (A1ATD) is potentially associated with a high degree of liver and/or lung disease. Apart from the most frequent deficiency alleles, Pi S and Pi Z, some A1AT alleles of clinical significance may be easily misdiagnosed. This is typically the case of the Pi Mmalton variant which shares the same 'gain-of-function' liver toxicity than Pi Z and the sam...
OBJECTIVE Osteoporotic fracture is one of the most common health risks and aggravates the quality of life among postmenopausal women worldwide. In this study, osteoporosis-associated protein biomarkers were identified from urine of osteoporotic female Sprague-Dawley rats developed by ovariectomy. METHOD Four months after the operation, the bone mineral density of the femur of ovariectomized r...
BACKGROUND Alpha1-Antitrypsin (A1AT) deficiency is currently detectable by protein immunoassay, phenotyping, and genotyping of the S and Z mutations, but no fully automated method for standard biochemical analyzers is yet available. Here, we present a method that measures the antitryptic activity in serum. This method is rapid, automated, and allows the easy evaluation of a large cohort of pati...
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