Sesamin is a major lignan in sesame seed. We confirmed that ingestion of sesamin and α-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet. To elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and α-tocopherol. Six-week-old male Sprague-Dawley rats ...

Three species of kilka (Clupeonella spp.) in the Caspian Sea have a high commercial value. In Iran it is use to produce canned, marinated packs and paste in making sausage and nugget. Kilka is a nutritious fish with high level of iron and considerable level of polyunsaturated fatty acids making it prone to auto-oxidation. The quality of kilka is the most important factor affects on its products...

This study analyzed the chemical composition and β-carotene, tocopherol retinol content of meat (musculus longissimus lumborum, musculus gluteus maximus) from young rams fed different silage-based diets. The animals were divided into four groups depending on type silage in feed ration (hybrid ryegrass, Festulolium cv. Becva, Felopa, Paulita). concentrations examined lipophilic compounds measure...

Geuk (Momordica cochinchinensis spreng) tropical fruits, which are produced in Jeju Island, Korea, well known for containing high levels of carotenoids and α-tocopherol. In this study, geuk fruits were separated two parts (pulp; yellow-orange and seed aril; red). The extracts of geuk fruits were simultaneously analyzed for carotenoids and α-tocopherol contents using HPLC. The results showed tha...

The antioxidative activity of α-tocopherol and Trolox, a water-soluble carboxylic acid derivative of α-tocopherol, in an emulsion stabilized with the hydrophilic emulsifier, polyoxyethylene (20) sorbitan monolaurate, was evaluated by measuring the changes in linoleic acid content, peroxide value, and thiobarbituric acid value. The activity of α-tocopherol and Trolox to depress the autoxidation ...

Vitamin E is likely the most important antioxidant in the human diet and α-tocopherol is the most active isomer. α-Tocopherol exhibits anti-oxidative capacity in vitro, and inhibits oxidation of LDL. Beside this, α-tocopherol shows anti-inflammatory activity and modulates expression of proteins involved in uptake, transport and degradation of tocopherols, as well as the uptake, storage and expo...

OBJECTIVE To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn. METHOD This randomized clinical trial enrolled 99 healthy adult pregnant women; of these, 39 were assigned to the control group and 60 to the supplemented group. After an overnight fast, 5mL of blood and 2mL of colostrum were collected. A...

This cytogenetic and pharmacological study attempts to clarify genotoxicity-enhancement-effect of dl-α-tocopherol (one form of vitamin E) in combination with the herbicide 1,1'-dimetyl-4,4'-bipyridium dichloride (paraquat, PQ) on cultured anuran leukocytes using the superoxide dismutase-mimic Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (Mn(III)TMpyP), the hydrogen peroxide-scavenger catalase a...

Changes in antioxidant properties and degradation of bioactives in palm oil (PO) and rice bran oil (RBO) during deep-frying were investigated. The alpha (α)-tocopherol, gamma (γ)-tocotrienol and γ-oryzanol contents of the deep-fried oils were monitored using high performance liquid chromatography, and antioxidant activity was determined using 2-diphenyl-1-picryl hydrazyl (DPPH) radical scavengi...

Extended use of plant ingredients in Atlantic salmon farming has increased the need for knowledge on the effects of new nutrients and contaminants in plant based feeds on fish health and nutrient-contaminant interactions. Primary Atlantic salmon hepatocytes were exposed to a mixture of PAHs and pesticides alone or in combination with the nutrients ARA, EPA, α-tocopherol, and γ-tocopherol accord...