Background and Aims: For many centuries herbs spices have traditionally been used to treat or manage a variety of diseases. The formulation food supplements containing single multiple is now popular. These formulations provide biochemical, pharmacological medicinal benefits due their diverse phytochemical constituents. Methods: In the present study, Diapin® – supplement Olea europaea L. leaves...

The anti-diabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed) was investigated using inhibitory assays for α-glucosidase, α-amylase, aldose reductase, glycation at multiple stages. Using activity-guided repeated fractionation on a silica gel column chromatography, dietary flavonoid rutin potent antihyperglycemic activity extracted from the methanol extract flour (MJ). ...

In this study, Limosilactobacillus fermentum PTCC 1638 and Lacticaseibacillus rhamnosus 1637 were used alone in combination to ferment quinoa seeds, the effect of fermentation (37 °C; 24 h) on pH, total phenols, tocopherols, vitamin C, antioxidant activity, enzymes inhibition (α-amylase α-glucosidase; antidiabetic effect) was investigated. The results showed that with increase time, bacterial p...

Type II diabetes mellitus is a common disease in the world and characterized by hyperglycemia. Prevention of reducing hyperglycemia depends on inhibition α-amylase α-glucosidase enzymes. In this study, antidiabetic profiles Paliurus spina-christi Mill. fruit were investigated. The species used as an folk medicine Turkey. inhibitory effect studies conducted to prove effect. n-hexane sub-extract ...

The periodic rise and frequency of diabetes mellitus (DM) have pressured into the quest for other possible anti-diabetic remedies from medicinal plants. foremost strategies engaged in lessening gastrointestinal glucose levels by hindrance carbohydrate digesting enzyme prominently as α-glucosidase . Acarbose, currently used an inhibitor, is a useful treatment option management hyperglycemia type...

the thermal denaturation of α-amylase from bacillus amyloliquefaciens has been investigated in the presence and absence of sodium dodecyl sulphate (sds) over the temperature range (293-373) k in 20 mm sodium phosphate buffer, ph 6.9, using temperature scanning spectroscopy. the presence of sds caused the destabilization of α-amylase resulting in a decrease in the temperature of unfolding with a...

Wheat starch degradation requires the synergistic action of different amylolytic enzymes. Our spatio-temporal study of wheat α-amylases throughout grain development shows that AMY3 is the most abundant isoform compared with the other known α-amylases. Endosperm-specific over-expression of AMY3 resulted in an increase of total α-amylase activity in harvested grains. Unexpectedly, increased activ...

The studies on the effects of arabinoxylan (AX) polysaccharides on postprandial glucose response have resulted in contrasting results owing to the diversity in AX structures. Four water extractable AX (WEAX) extracts obtained from wheat aleurone and bran were used to investigate (a) the effect of AX on activities of α-amylase and α-glucosidase, (b) influence of AX chemical composition on their ...

BACKGROUND There is a need to develop potential new therapies for the management of diabetes and hypertension. Australian medicinal plants collected from the Kuuku I'yu (Northern Kaanju) homelands, Cape York Peninsula, Queensland, Australia were investigated to determine their therapeutic potential. Extracts were tested for inhibition of protein glycation and key enzymes relevant to the managem...