19 Cynanchi Wilfordii Radix (baishouwu), a medicinal herb, has been widely used in Asia to 20 treat a variety of diseases or illnesses. Cynandione A isolated from C. Wilfordii is the 21 principle acetophenone and exhibits neuroprotective and anti-inflammatory activities. This 22 study aims to evaluate the antihypersensitivity activities of cynandione A in neuropathy and 23 explored its mechanis...

ß-Glucogallin (1 -O-galloyl-ß-D-glucopyranose), 1,6-Di-O-galloyl-ß-D-glucopyranose, Acyltransferase, Gallotannin Biosynthesis, Quercus robur Cell-free extracts from oak (Quercus robur) leaves catalyze the transfer of the galloyl-moiety of ß-glucogallin (1-O-galloyl-ß-D-glucopyranose) specifically to the 6-position of the same compound, yielding 1,6-di-O-galloyl-ß-D-glucopyranose, an intermediat...

The post-translational processing of pro-opiomelanocortin (POMC) in brain remains controversial. Classically, there was thought to be a single cell group in the arcuate nucleus with long projections through limbic structures. More recently, a second cell group was discovered in the caudal medulla. This study addresses the question of POMC processing in this region. Steady-state analysis of acid...

background: the present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. methods: food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...

Although exogenous administration of beta-endorphin to the arcuate nucleus of hypothalamus (ARC) had been shown to produce antinociception, the role of endogenous beta-endorphin of the ARC in nociceptive processing has not been studied directly. The aim of the present study was to investigate the effect of endogenous beta-endorphin in the ARC on nociception in rats with carrageenan-induced infl...

β-Endorphin plays a major role in the amelioration of insulin resistance. The present study documents that myricetin (3,5,7,3', 4', 5'-hexahydroxyflavone) ameliorates insulin resistance by enhancing β-endorphin production in insulin-resistant rats. The rats were induced for insulin resistance by feeding them a diet containing 60% fructose for 6 weeks. The degree of insulin resistance was measur...

The classical analgesic pathway of opioids by binding their receptors in the nervous system is well known. However, little is known regarding opioid analgesia through the anti-inflammatory pathway. The present study aimed to investigate the analgesic and anti-inflammatory effect of β-endorphin on inflammatory pain. A rat model of collagen-induced arthritis (CIA) was generated by intradermal inj...

Five peptides derived from pro-corticotropin/endorphin (pro-ACTH/endorphin), the pituitary corticotroph cell prohormone, were bioassayed with isolated rat adrenocortical cells: alpha- and beta-melanotropin, beta-lipotropin, beta-endorphin, and the amino-terminal region of pro-ACTH/endorphin known as "16k fragment." The effect of each on steroidogenesis was measured at potentially physiological ...

ß -carotene is a human nutrient found in plants or animals. It is also can be synthesized chemically. It is lipid-soluble, and is yellow, orange or red in color. ß-Carotene can be cleaved into vitamin A in vivo. The most abundant form of ß-carotene in human serum is trans isomer; cis isomers such as 9-cis ß-carotene, 13-cis ß-carotene, and 15-cis ß-carotene are only present in trace amounts. ß-...

We hypothesized that, in the airway mucosa, opioids are inhibitory neural modulators that cause an increase in net water absorption in the airway mucosa (as in the gut). Changes in bidirectional water fluxes across ovine tracheal mucosa in response to basolateral application of the opioid peptides beta-endorphin, dynorphin A-(1-8), and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE) were measured. beta...