A new concept in multifunctional anticancer agents is demonstrated. Tetrakis-(diisopropyl-guanidino) zinc phthalocyanine (Zn-DIGP) exhibits excellent properties as a photodynamic therapy (PDT) agent, as well as potential anti-metastatic activities in vivo. Zn-DIGP exhibits good cellular uptake and low toxicity in the dark (EC50 > 80 μM) and is well tolerated upon its intravenous injection into ...

Epigenetic changes are inherited alterations in DNA that affect gene expression and function without altering the DNA sequence. DNA methylation is one epigenetic process implicated in human disease that is influenced by diet. DNA methylation involves addition of a 1-C moiety to cytosine groups in DNA. Methylated genes are not transcribed or are transcribed at a reduced rate. Global under-methyl...

Humanoid robots selectively emulate aspects of human form and behavior. Humanoids come in a variety of shapes and sizes, from complete human-size legged robots to isolated robotic heads with human-like sensing and expression. This chapter highlights significant humanoid platforms and achievements, and discusses some of the underlying goals behind this area of robotics. Humanoids tend to require...

Resident Perspective: Inflammatory markers of complete blood count in Fuchs uveitis syndromeUnderstanding the underlying etiology and pathophysiology ophthalmological disorders is paramount to achieving early diagnosis improved patient outcomes. Although syndrome (FUS) a well-established recognized disorder characterized by chronic, low-grade anterior uveitis, precise this not yet fully underst...

A bioaccessibility test with raw and cooked lamb meat samples was performed. The evaluated cooking devices were grill, microwave oven, air fryer, pressure cooker, electric oven. Physicochemical parameters the total mass fraction of Cu, Fe, K, Mg, P, Zn determined in by inductively coupled plasma optical emission spectrometry (ICP OES). trueness using certified reference materials, recoveries fr...

The Dirac spin liquid ground state of the spin 1/2 Heisenberg kagome antiferromagnet has potential instabilities. This has been suggested as the reason why it does not emerge as the ground state in large-scale numerical calculations. However, previous attempts to observe these instabilities have failed. We report on the discovery of a projected BCS state with lower energy than the projected Dir...

Using structure-directing agents, pore space partitions of a Zn-phosphonocarboxylate framework have been achieved. Selective adsorption of CO(2) over N(2) has been greatly improved from ca. 9 : 1 to 94 : 1.

Fixed angle surface plasmon coupled fluorescence (SPCF) from iron thin films is demonstrated for the first time. The optimum thickness of the iron thin films was determined to be 15 nm using Fresnel calculations. The angles of minimum reflectivity for light at 496-814 nm were predicted to occur at a fixed and broad range of angles of 60-70°. Experimental corroboration of these predictions were ...