Vegetable oils are being investigated as potential source of environmentally favorable lubricants over synthetic products. Jatropha curcas L. oil (JO) identified as a potential raw material for biodiesel was explored for its use as a feedstock for biolubricants. Epoxidized jatropha oil (EJO) was prepared by peroxyformic acid generated in situ by reacting formic acid and hydrogen peroxide in the...

Background: Novel anti-tumor bioactivity compounds were designed by the strategy of modular hybridization with advantages 5-fluorouracil and dithiocarbamate derivatives. Methods: A series novel 5-fluorouracil-dithiocarbamate conjugates synthesized, characterized evaluated for their cytotoxic activities in vitro against B16, Hela U87MG MTT assay. Colony-formation, transwell migration, cell apopt...

A series of novel naphthalimide dithiocarbamate 4a-f, 5a-f were efficiently synthesized via introduce dithiocarbamate and dithioate side chain onto the naphthalic anhydride core. The structures of the synthesized analogs were elucidated by spectroscopic methods, including IR, 1H and 13C NMR, and (ESIHRMS) techniques. The anti-cancer activities of the generated naphthalimide derivatives 4c, 4d, ...

N,N-bis(beta-Hydroxyethyl)dithiocarbamate (DHDC), N-methyl-N-hydroxyethyldithiocarbamate (MHDC), and N-ethyl-N-hydroxyethyldithiocarbamate (EHDC) were compared for their relative efficacies in promoting organ mobilization and excretion of metallothionein-bound cadmium (Cd). An attempt was made to correlate certain aspects of their pharmacodynamic properties with the octanol/aqueous partition co...

Two new ligands, ammonium 2,6-dimethyl morpholine dithiocarbamate (ADMMDTC) and ammonium 3-methyl piperdine dithiocarbamate (AMP-DTC) were synthesized in the laboratory. The method was based on chelation of manganese(II) with ADMM-DTC/AMP-DTC in the presence of NH4OH at pH 6.2 and 6.8 to produce catalytic hydrogen currents at -0.72 V and -0.62 V vs. SCE respectively and prior detected by D.C po...

An efficient methodology to obtain novel antifungal analogs of brassinin 1 is described. Starting from l-tryptophan 2, N,N'-dialkylthiourea 4, 4-[(1H-indol-3-yl)methylene]-2-sulfanylidene-1,3-thiazolidin-5-one 5 and alkyl (2S)-3-(1H-indol-3-yl)-2-{[(alkylsulfanyl)carbonothioyl]amino}propanoate 6 type compounds were obtained as main products in different ratios depending on the reaction conditio...

A large number of piperidyl quinolinemethanols were investigated for antimalarial activity in avian infections because of close chemical similarity to quinine, as part of the wartime search for new and more effective antimalarial agents. In preliminary observations, SN-10,275,3 or 6,8-dichloro-2phenyl-a-2-piperidyl4-quinolinemethanol (Figure 1), gave greatest indication of promise. It is a comp...