We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indicator of drug-induced QT interval prolongation. To investigate the applicability of the hES-CMC system to drug safety assessment, we investigated short-term variability in FPDc (STV...

The minimum mass that a virialized gas cloud must have in order to be able to cool in a Hubble time is computed, using a detailed treatment of the chemistry of molecular hydrogen. With a simple model for halo profiles, we reduce the problem to that of numerically integrating a system of chemical equations. The results agree well with numerically expensive 3D simulations, and our approach has th...

A lattice structure based on the singular value decomposition (SVD) is introduced. The lattice can also be proven to use a minimal number of delay elements and to completely span a large class of M-channel linear phase perfect reconstruction filter bank (LPPRFB): all analysis and synthesis filters have the same FIR length of L = K M , sharing the same center of symmetry. The lattice also struct...

Photoisomerisation of protonated azobis(2-imidazole), an intramolecular hydrogen-bonded azoheteroarene photoswitch molecule, is investigated in the gas phase using tandem ion mobility mass spectrometry. The E and Z isomers exhibit distinct spectral responses, with E-Z photoisomerisation occurring over the 360-520 nm range (peak at 460 nm), and Z-E photoisomerisation taking place over the 320-42...

The minimum mass that a virialized gas cloud must have in order to be able to cool in a Hubble time is computed, using a detailed treatment of the chemistry of molecular hydrogen. With a simple model for halo prooles, we reduce the problem to that of numerically integrating a system of chemical equations. The results agree well with numerically expensive 3D simulations, and our approach has the...

In this paper, we use a simple and parsimoniousmodel to investigate the performance of volume discounting schemes (hereafter ‘‘[VD]’’) in a supply chain where the market demand is sensitive to both retail price ‘‘p’’ and sales effort ‘‘e’’ — hereafter called a ‘‘(p,e)-channel.’’ The problem is analyzed as a manufacturer-leading Stackelberg game. We first present, for the deterministic-system-pa...

A whole-of-band receiver structure is proposed. In this structure, the whole mobile band (125 channels for G S M ) is digitized and channel selection is performed using D S P filters. The A D C is a critical component in this structure, requiring 13bits resolution at sampling rate of 5 0 M H z . A modified Z A A D C converter is proposed for this application. The Z A A D C must be able to null ...

BACKGROUND AND AIMS Seagrasses are important facilitator species in shallow, soft-bottom marine environments worldwide and, in many places, are threatened by coastal development and eutrophication. One narrow-leaved species (Zostera marina) and one wide-leaved species, variously designated as Z. marina, Z. pacifica or Z. asiatica, are found off the California Channel Islands and adjacent Califo...

BACKGROUND To compare the characteristics between 22-channel water-perfusion manometry (WPM) and solid-state manometry (SSM) with 36 sensors of the pressure measurements, as well as patients' discomfort indices in nose and pharynx, the preparation and operation time of the manometry. METHODS 12 volunteers were included in the study. Each of the volunteers underwent esophageal manometry by bot...

The minimal $U(1{)}_{X}$ extension of the Standard Model (SM) is a well-motivated new physics scenario, where anomaly cancellation dictates neutral gauge boson (${Z}^{\ensuremath{'}}$) couplings with SM fermions in terms charges scalar fields. We investigate charged fermion pair-production process for different values these at future ${e}^{\ensuremath{-}}{e}^{+}$ colliders: ${e}^{+}{e}^{\ensure...