Two dosage regimens of L-asparaginase were investigated to determine differences in the production of abnormal reactions and remission induction. Patients were randomly assigned to receive 200 i.u./kg daily for 14 days (Regimen A) or 1000 i.u./kg twice weekly for 2 weeks (Regimen B). All were in relapse and refractory to several chemotherapeutic agents. Medianduration of diseasewas 11 months in...

Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. The purpose of this investigation was evaluation of response and tolerability to neoadjuvant EOX regimen in locoregionally advanced gastric cancer. Materials and Methods: patients with locoregionally adv...

BACKGROUND Dysmenorrhea is a common condition in women, which is characterized by menstrual pain. Low-dose estrogen/progestin combined oral contraceptives have been shown to reduce the severity of dysmenorrhea symptoms, and a 28-day cyclic regimen of ethinylestradiol/drospirenone (28d regimen) is approved for this indication in Japan. AIM The aim of this study was to assess the safety and eff...