نتایج جستجو برای: yap gene

تعداد نتایج: 1145607  

2015
Ming Liu Xiu-Ping Wang

To identify the downstream target genes of YAP, we used RNA-Seq technology to compare the transcriptomic profilings of Yap conditional knockout (Yap CKO) and YAP over-expression mouse tooth germs. Our results showed that some Hox, Wnt and Laminin family genes had concurrent changes with YAP transcripts, indicating that the expression of these genes may be regulated by YAP. Here, we provide the ...

Journal: :Cancer research 2015
Hiromitsu Hayashi Takaaki Higashi Naomi Yokoyama Takayoshi Kaida Keita Sakamoto Yukiko Fukushima Takatsugu Ishimoto Hideyuki Kuroki Hidetoshi Nitta Daisuke Hashimoto Akira Chikamoto Eiji Oki Toru Beppu Hideo Baba

Transcriptional coactivator with PDZ-binding motif (TAZ) and yes-associated protein (YAP) are equivalently placed downstream effectors of the Hippo pathway with oncogenic roles in human cancers. However, the expression profiles of TAZ/YAP differ depending on the cancer cell type, suggesting that these proteins have different roles during cancer progression, yet no studies have examined the biol...

2017
Elena Ghiso Cristina Migliore Vito Ciciriello Elena Morando Annalisa Petrelli Simona Corso Emmanuele De Luca Gaia Gatti Marco Volante Silvia Giordano

The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased metastatic ability. Moreover, it has recently been shown that YAP plays a role in sustaining res...

2016
Colleen A. Fullenkamp Sarah L. Hall Omar I. Jaber Brittany L. Pakalniskis Erica C. Savage Johanna M. Savage Georgina K. Ofori-Amanfo Allyn M. Lambertz Stephanie D. Ivins Christopher S. Stipp Benjamin J. Miller Mohammed M. Milhem Munir R. Tanas

TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcomas demonstrate activation of YAP while 66% of sarcomas demonstrate activated TAZ. Differential act...

2015
Qinghe Song Beibei Mao Jinbo Cheng Yuhao Gao Ke Jiang Jun Chen Zengqiang Yuan Songshu Meng

The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor suppressor pathway, functions as an oncoprotein in a variety of cancers. However, its contribution to breast cancer remains controversial. This study investigated the role of YAP in breast cancer cells under nutrient deprivation (ND). Here, we show that YAP knockdown sensitized MCF7 breast cancer cell...

2016
Dashun Huang Xiaojiao Li Li Sun Ping Huang Hao Ying Hui Wang Jiarui Wu Haiyun Song

The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats. Here we identify the p38 mitogen-activated protein kinase (MAPK) pathway as a new upstr...

2015
Alexandra Karystinou Anke J Roelofs Anna Neve Francesco P Cantatore Henning Wackerhage Cosimo De Bari

INTRODUCTION The control of differentiation of mesenchymal stromal/stem cells (MSCs) is crucial for tissue engineering strategies employing MSCs. The purpose of this study was to investigate whether the transcriptional co-factor Yes-associated protein (YAP) regulates chondrogenic differentiation of MSCs. METHODS Expression of total YAP, its paralogue transcriptional co-activator with PDZ-bind...

2016
Hui Li Zhenglan Huang Miao Gao Ningshu Huang Zhenhong Luo Huawei Shen Xin Wang Teng Wang Jing Hu Wenli Feng

BACKGROUND Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS The expression of YAP in CML cells was determined by western blotting. Next, the effects of YAP knockdown and YAP inhibitor ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Minghui Yao Yadong Wang Peng Zhang Hong Chen Zhiheng Xu Jianwei Jiao Zengqiang Yuan

Previous studies have shown that the Hippo pathway effector yes-associated protein (YAP) plays an important role in maintaining stem cell proliferation. However, the precise molecular mechanism of YAP in regulating murine embryonic neural stem cells (NSCs) remains largely unknown. Here, we show that bone morphogenetic protein-2 (BMP2) treatment inhibited the proliferation of mouse embryonic NSC...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید