نتایج جستجو برای: yac

تعداد نتایج: 835  

Journal: :Molecular and cellular biology 1996
C B Bennett T J Westmoreland J R Snipe M A Resnick

Human chromosomal DNA contains many repeats which might provide opportunities for DNA repair. We have examined the consequences of a single double-strand break (DSB) within a 360-kb dispensable yeast artificial chromosome (YAC) containing human DNA (YAC12). An Alu-URA3-YZ sequence was targeted to several Alu sites within the YAC in strains of the yeast Saccharomyces cerevisiae; the strains cont...

2006
Dirk A. Kleinjan Anne Seawright Sebastien Mella Catherine B. Carr David A. Tyas T. Ian Simpson John O. Mason David J. Price Veronica van Heyningen

Pax6 is a developmental control gene with an essential role in development of the eye, brain and pancreas. Pax6, as many other developmental regulators, depends on a substantial number of cis-regulatory elements in addition to its promoters for correct spatiotemporal and quantitative expression. Here we report on our analysis of a set of mice transgenic for a modified yeast artificial chromosom...

Journal: :The Plant journal : for cell and molecular biology 1999
T Ito M Seki N Hayashida D Shibata K Shinozaki

For regional insertional mutagenesis of Arabidopsis thaliana genes, we combined a cDNA scanning method (Hayashida et al. Gene 1995; 165:155-161) and an Ac/Ds transposon designed for local mutagenesis, and evaluated this approach with two overlapping yeast artificial chromosome (YAC) clones, CIC7E11 and CIC8B11, on A. thaliana chromosome 5. We applied a previously developed novel cDNA selection ...

Journal: :Brain : a journal of neurology 2009
Mahmoud A Pouladi Rona K Graham Joanna M Karasinska Yuanyun Xie Rachelle Dar Santos Asa Petersén Michael R Hayden

Huntington disease is a neurodegenerative disorder caused by an expanded CAG repeat in the Huntington disease gene. The symptomatic phase of the disease is defined by the onset of motor symptoms. However, psychiatric disturbances, including depression, are common features of Huntington disease and recent studies indicate that depression can occur long before the manifestation of motor symptoms....

Journal: :Journal of the National Cancer Institute 1999
K Jülicher G Marquitan N Werner W Bardenheuer L Vieten F Bröcker H Topal S Seeber B Opalka J Schütte

BACKGROUND Alterations of chromosome region 3p14 are observed in numerous human malignancies. Because the pattern of allelic losses suggests the existence of at least one tumor suppressor gene within this region, we established a library of yeast artificial chromosomes (YACs) containing contiguous human 3p14 sequences to permit a search for tumor suppressor loci within the 3p14 region by use of...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Jing Fan Catherine M Cowan Lily Y J Zhang Michael R Hayden Lynn A Raymond

Evidence suggests that NMDA-type glutamate receptors contribute to degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). Previously, we demonstrated that NMDA receptor (NMDAR)-mediated current and/or toxicity is increased in MSNs from the yeast artificial chromosome (YAC) transgenic mouse model expressing polyglutamine (polyQ)-expanded (mutant) full-length hum...

Journal: :Blood 1995
M Taniwaki G A Sliverman K Nishida S Horiike S Misawa C Shimazaki I Miura M Nagai M Abe S Fukuhara

Translocation of the BCL2 gene in B-cell malignancies carrying t(14;18) and amplification of the BCL2 gene in a cell line (HBL-2) derived from a non-Hodgkin's lymphoma (NHL) were detected specifically in both metaphase spreads and interphase nuclei by fluorescence in situ hybridization (FISH) using yeast artificial chromosomes (YACs). A YAC clone containing the BCL2 gene yA153A6, a 360-kb clone...

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