This study investigated whether a novel ionogenic substance, containing amongst others zinc and rubidium (PHI-5; Dermagenics Inc, Memphis, TN, USA), could improve the healing of full-thickness skin wounds. Uniform wounds were created on the right flank of guinea pigs. Micro-grooved silicone rubber membranes, containing 0 (controls), 1.25, 5.00, or 10.00 microg PHI-5, were sutured onto this woun...

Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical an...

PURPOSE: Large surface area wounds, resulting from burns, trauma, or iatrogenic injury, often result in significant scarring and wound contracture. Despite treatment with any of the currently available gold-standard therapies, contracture can still develop as a sequelae of the process of normal wound healing, specifically, myofibroblast activity. Photochemical Tissue Passivation (PTP) is a proc...

PURPOSE: Large surface area wounds, resulting from burns, trauma, or iatrogenic injury, often result in significant scarring and wound contracture. Despite treatment with any of the currently available gold-standard therapies, contracture can still develop as a sequelae of the process of normal wound healing, specifically, myofibroblast activity. Photochemical Tissue Passivation (PTP) is a proc...

background: plants and their phytochemicals have immense potential for the management of different types of wound. salvia multicaulis vahl. is an evergreen shrub species, which traditionally used as a wound healing agent. objective: the aim of the present study is to evaluate phytochemicals and wound healing activity of s. multicaulis in an excision wound model. methods: preliminary phytochemic...

 Many chronic wounds have a limited blood supply and contain necrotic tissue that must be debrided. The effect of collagenase, an enzymatic debriding agent, has been studied in acute but not in chronic wounds. The purpose of this in vivo study is to evaluate the effect of collagenase on wound healing in ischemic wounds. The ears of eight young New Zealand White rabbits were rend...

OBJECTIVE To evaluate the clinical efficacy of Negative Pressure Wound Therapy (NPWT) using Vacuum Assisted Closure (VAC) compared with Advanced Moist Wound Therapy (AMWT) to treat Diabetic Foot Ulcer (DFU). STUDY DESIGN Randomized control trial. PLACE AND DURATION OF STUDY Surgical Department, Combined Military Hospital (CMH) / Military Hospital (MH), Rawalpindi, from November 2010 to June...

-------------------------------------------------------------------------------SUMMARY. The purpose of this experimental study was to evaluate the efficacy of moist exposed bum ointment (MEBO) on epithelial tissue repair and to assess the debriding effect of partial-thickness bum wounds, compared with other local agents commonly used. Eighty bum wounds on ten Ladrace-Pietrenne youngi pigs were ...

Background and aim: Shortening of the duration of wound healing is an attractive subject for investigators in recent years. In this study, the effects of topical phenytoin, silver sulfadiazine, estrogen and their combination on wound healing were evaluated.Materials and Methods: This experimental study was accomplised on 30 male albino rats, which had an approximate wei...