نتایج جستجو برای: wnt signalling and hek293t cells

تعداد نتایج: 17086001  

Journal: :Journal of cell science 2006
Gary J Spencer Jennifer C Utting Sharon L Etheridge Timothy R Arnett Paul G Genever

Reports implicating Wnt signalling in the regulation of bone mass have prompted widespread interest in the use of Wnt mimetics for the treatment of skeletal disorders. To date much of this work has focused on their anabolic effects acting on cells of the osteoblast lineage. In this study we provide evidence that Wnts also regulate osteoclast formation and bone resorption, through a mechanism in...

Journal: :Development 2011
Pilar Esteve Africa Sandonìs Carmen Ibañez Akihiko Shimono Isabel Guerrero Paola Bovolenta

Secreted frizzled-related proteins (Sfrps) are considered Wnt signalling antagonists but recent studies have shown that specific family members enhance Wnt diffusion and thus positively modulate Wnt signalling. Whether this is a general and physiological property of all Sfrps remains unexplored. It is equally unclear whether disruption of Sfrp expression interferes with developmental events med...

Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin signaling pathway.Materials and Methods: Eca109 cells were classified into 5 groups: Control group, H2O2 group, Propofol + H2O2 group, Dkk1 (Dickkopf-1, Wnt/β-catenin pathway antagonist) + H2O2 group...

Journal: :Development 2006
Soline Estrach Carrie A Ambler Cristina Lo Celso Katsuto Hozumi Fiona M Watt

The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing int...

Journal: :The EMBO journal 2011
Jean-Paul Vincent Karen Beckett

Like many other signalling pathways, the Wnt pathway is seen as part of a network that integrates extracellular information mediated by a variety of cell surface proteins to produce cell context-specific outputs. The identification of Frizzled as Wnt receptors (Bhanot et al, 1996) provided the essential link between extracellular Wnts and the intracellular components of Wnt signal transduction....

Journal: :Development 2003
Kelly Anakwe Lesley Robson Julia Hadley Paul Buxton Vicki Church Steve Allen Christine Hartmann Brian Harfe Tsutomu Nohno Anthony M C Brown Darrell J R Evans Philippa Francis-West

The limb musculature arises by delamination of premyogenic cells from the lateral dermomyotome. Initially the cells express Pax3 but, upon entering the limb bud, they switch on the expression of MyoD and Myf5 and undergo terminal differentiation into slow or fast fibres, which have distinct contractile properties that determine how a muscle will function. In the chick, the premyogenic cells exp...

Journal: :Development 2008
Penelope Hayward Tibor Kalmar Alfonso Martinez Arias

The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch ('Wntch') signalling act as components of a...

2015
Iris Sawitza Claus Kordes Silke Götze Diran Herebian Dieter Häussinger

Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with growth factors. Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-der...

2016
Minkyung Shin Eun Hee Yi Byung-Hak Kim Jae-Cheon Shin Jung Youl Park Chung-Hyun Cho Jong-Wan Park Kang-Yell Choi Sang-Kyu Ye

The β-catenin functions as an adhesion molecule and a component of the Wnt signaling pathway. In the absence of the Wnt ligand, β-catenin is constantly phosphorylated, which designates it for degradation by the APC complex. This process is one of the key regulatory mechanisms of β-catenin. The level of β-catenin is also controlled by the E3 ubiquitin protein ligase SIAH-1 via a phosphorylation-...

Journal: :Frontiers in bioscience : a journal and virtual library 2007
Elizabeth Vincan Rajeeb Kumar Swain Thomas Brabletz Herbert Steinbeisser

Recent insights from diverse fields of basic and clinical research reveal that the biological processes that govern embryonic development and organogenesis are also commonly involved in the pathologies that arise in that organ or tissue in the adult. This striking parallel between embryonic development and pathology is exemplified by Wnt signalling in the intestinal tract. Wnt signalling is cri...

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