Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it varies drastically among the tumors' origins, stages, and organs, owing much to differences in vessel leakiness. Suboptimal EPR effect represents a major problem in the translation of nanomedicine to the clinic....

In this study, electron paramagnetic resonance (EPR) is used, for the first time, as an analytical tool for the quantitative assay of ketoconazole (KTZ) in drug formulations. The drug was successfully characterized by the prominent signals by two radical species produced as a result of its oxidation with 400 microg/mL cerium(IV) in 0.10 mol dm(-3) sulfuric acid. The EPR signal of the reaction m...

Free radicals in the original and sterilized caraway, curry, curcuma and cardamom were studied. An X-band (9.3 GHz) electron paramagnetic resonance (EPR) spectroscopy was the experimental technique. Effect of microwave power in the range of 2.2-70 mW on amplitudes, linewidths, and lineshape parameters of the EPR spectra was tested. Free radicals concentrations in the non- and sterilized herb sa...

We present a scheme for the first-principles calculation of EPR lineshapes for continuous-wave-EPR spectroscopy (cw-EPR) of spin centers in complex chemical environments. We specifically focus on poorly characterized systems, e.g. powders and frozen glasses with variable microsolvation structures. Our approach is based on ab initio molecular dynamics simulations and ab initio calculations of th...

Ferrous hemeproteins and inorganic heme complexes react with nitric oxide to form six-coordinate paramagnetic complexes. These complexes exhibit strong EPR signals centered near g = 2.0 which are easily observed in frozen solution. We have obtained EPR spectra of the nitrosyl adducts of Fe(II) protoporphyrin IX-imidazole in dimethylsulfoxide and in dimethylformamide, and of myoglobin, cytochrom...

Two methods are compared that are used in path integral simulations. Both methods aim to achieve faster convergence to the quantum limit than the so-called primitive algorithm (PA). One method, originally proposed by Taka-hashi and Imada, is based on a higher-order approximation (HOA) of the quantum mechanical density operator. The other method is based upon an effective propagator (EPr). This ...

Two methods are compared that are used in path integral simulations. Both methods aim to achieve faster convergence to the quantum limit than the so-called primitive algorithm (PA). One method, originally proposed by Taka-hashi and Imada, is based on a higher-order approximation (HOA) of the quantum mechanical density operator. The other method is based upon an effective propagator (EPr). This ...

Currently electron paramagnetic resonance (EPR) retrospective biodosimetry with tooth enamel can measure doses as low as 30 mGy. This method uses commercial X-band (9.5 GHz) EPR spectrometers and specially prepared samples from tooth enamel. One of the disadvantages of X-band EPR dosimetry is the requirement to obtain isolated teeth from a cohort of interest. In vivo EPR retrospective biodosime...

Electron paramagnetic resonance (EPR) spectroscopy may be applied to examine interactions of melanin with metal ions and drugs. In this work EPR method was used to examination of changes in free radical system of DOPA-melanin--the model eumelanin after complexing with diamagnetic cadmium(II) ions. Cadmium(II) may affect free radicals in melanin and drugs binding by this polymer, so the knowledg...