Acting upon clinical patient data, acquired in the pathway of percutaneous intervention, we deploy hierarchical, multi-stage, data-handling protocols and interacting low- high-order mathematical models (chamber elastance, state-space system CFD models), to establish then validate a framework quantify burden ischaemia. Our core tool is compartmental, zero-dimensional model coupled circulation wi...

Inlet and outlet boundary conditions (BCs) play an important role in newly emerged image-based computational hemodynamics for blood flows human arteries anatomically extracted from medical images. We developed physiological inlet BCs based on patients’ data integrated them into the volumetric lattice Boltzmann method. The BC is a pulsatile paraboloidal velocity profile, which fits real arterial...

UNLABELLED Changes in contraction and relaxation parameters during chronic electrical stimulation can exert profound effects on diastolic augmentation during skeletal muscle assistance (SMA) of the circulation, in both short and long term. The physiological properties of latissimus dorsi muscle (LD) performance in a system that mimics the clinical setting has not been adequately studied. OBJE...

Computational fluid dynamics (CFD) study of hemodynamics in the aorta can provide a comprehensive analysis relevant cardiovascular diseases. One trending approach is to couple three-element Windkessel model with patient-specific CFD simulations form multi-scale that captures more realistic flow fields. However, case-specific parameters (e.g., Rc, Rp, and C) for must be tuned reflect conditions....

Stimulus evoked changes in cerebral blood flow, volume, and oxygenation arise from responses to underlying neuronally mediated changes in vascular tone and cerebral oxygen metabolism. There is increasing evidence that the magnitude and temporal characteristics of these evoked hemodynamic changes are additionally influenced by the local properties of the vasculature including the levels of basel...

Controversy exists about whether one-dimensional wave theory can explain the "self-canceling" waves that accompany the diastolic pressure decay and discharge of the arterial reservoir. Although it has been proposed that reservoir and wave effects be treated as separate phenomena, thus avoiding the issue of self-canceling waves, we have argued that reservoir effects are a phenomenological and ma...

BACKGROUND Counter-pulsation control (CPC) by ventricular assist devices (VADs) is believed to reduce cardiac load and increase coronary perfusion. However, patients with VADs have a higher risk of arrhythmia, which may cause the CPC to fail. Consequently, CPC has not been applied by VADs in clinical practice. The phase-locked loop (PLL) algorithm for CPC is readily implemented in VADs; however...