The first total synthesis of the marine prostanoids clavulolactones II and III is presented from an easily accessible chiral, non-racemic cyclopentenone intermediate. Key steps involve selective TBDMS deprotection, selective reduction of the β-side chain and aldol condensation. Clavulolactones II and III were successfully prepared from (S)-4-((tert-butyldimethylsilyl)oxy) cyclopent-2-en-1-one o...

There is a wide area of applications that use embedded systems, and the number of such systems keeps growing. The required functionality and complexity of embedded systems are also constantly increasing, and development of such products is becoming increasingly harder. This requires new thinking on the product development processes, and one such emerging philosophy is the agile methods. These m...

abstract:turmeric is a member of the ginger family (zingiberaceae), which is extensively used as a spice, food preservative and colouring material. curcumin is a main bioactive natural compound derived from the rhizome of this plant. curcumin can exist in several tautomeric forms, keto and enol. the keto form is more stable than enol form. silyl ethers have proven to be versatile substrates for...

background and objectives: high performance research activity in the health domain is crucial to overcoming ever-growing health-related problems. despite availability of data sources, only a limited number of researchers use these data to derive health-related information. thus, the present study aimed at exploring the barriers to research promotion as perceived by the university health researc...

Background: DNA immunization is an appropriate method to produce an immunological response. Pseudomonas aeruginosa produces exotoxin A which is highly cytotoxic for eukaryotic cells. Since domains II (translocation domain) and 1b of the toxin have antigenic qualities, so they could be  useful candidates to protect against pseudomonas infections. Objectives: To evaluate if recombinant plasmid co...

a time-domain approach is presented to calculate electromagnetic fields inside a large electromagnetic pulse (emp) simulator. this type of emp simulator is used for studying the effect of electromagnetic pulses on electrical apparatus in various structures such as vehicles, a reoplanes, etc. the simulator consists of three planar transmission lines. to solve the problem, we first model the meta...

pyrano [2,3-d] pyrimidinone derivatives have received considerable interest from the pharmaceutical industry due to their wide range of interesting biological and therapeutic properties. nano al2o3 was found to be a highly efficient solid acid catalyst for the preparation of pyrano [2,3-d] pyrimidinone derivatives from the reaction of barbituric acid, aryl aldehyde and malononitrile. al2o3 nano...