BACKGROUND The case fatality rate of severe malaria remains unacceptably high. N-acetylcysteine (NAC) is a safe compound that inhibits tumour necrosis factor (TNF) and impedes cytoadherence, both of which have been implicated in the pathogenesis of malaria complications. AIM To evaluate NAC as adjunctive therapy in severe malaria. DESIGN A placebo-controlled, double-blind prospective study,...

INTRODUCTION Early detection of social anxiety and loneliness might be useful to prevent substantial impairment in personal relationships. Understanding the way people use smartphones can be beneficial for implementing an early detection of social anxiety and loneliness. This paper examines different types of smartphone usage and their relationships with people with different individual levels ...

We determined the cerebrospinal fluid (CSF) levels of adenosine, a mediator of cerebral blood flow regulation, and neopterin, a macrophage-producing compound, in patients with neurological disorders. Compared to control subjects, the adenosine levels were significantly increased in the patients with acute-stage cerebral infarction (n=12, p<0.0001), acute meningitis (n=10, p<0.0001), or amyotrop...

This study evaluated the influence of irrigation tip, root canal curvature and final apical diameter on periapical debris and irrigant extrusion during root canal instrumentation. After being classified as mildly or moderately curved, the mesiobuccal root canals of 90 human molars were instrumented. The teeth were allocated into three groups according to the used needle type: a flat open-end ne...

A case-control study was performed to assess the serum levels of TNF-α, IL-12/23p40, and IL-17 in patients with plaque psoriasis, compare them with healthy controls, and correlate them with disease severity, as represented by Psoriasis Area Severity Index (PASI). 32 consecutively selected, untreated patients with active, chronic plaque psoriasis were recruited and compared to 32 age- and sex-ma...

Objectives. To determine if hyperopia is a risk factor for primary angle-closure glaucoma (PACG) in the Dutch population and to identify other biometrical parameters as risk factors for PACG including axial length (AL), anterior chamber depth (ACD), and k values. Methods. The study population consisted of PACG patients that had undergone a laser peripheral iridotomy (LPI). The control group con...

Likert items and scales are often used in human subject studies to measure subjective responses of subjects to the treatment levels. In the field of human-robot interaction (HRI), with few widely accepted quantitative metrics, researchers often rely on Likert items and scales to evaluate their systems. However, there is a debate on what is the best statistical method to evaluate the differences...

PURPOSE The objective of this study was to evaluate morphological changes of the mandible in edentulous and dentate subjects using panoramic radiographs. MATERIALS AND METHODS Panoramic radiographs were divided into the following three groups: Group I (completely edentulous group), Group II (old dentate group) and Group III (young dentate group). The research parameters of gonial angle, condy...

Methods Patient blind, parallel group, randomised, controlled study of two study arm. 54 patients were given AST (GroupA) and control group of 57 patients given injection normal saline (placebo) (GroupB). AST/Placebo was given every week for 9 weeks and then followed-up for another 3 weeks. Levocetrizine was advised to be taken SOS in both groups. AU was diagnosed by autologous serum skin test....