The protein-serine kinase Shaggy (Sgg) is the Drosophila homolog of mammalian glycogen synthase kinase-3 and has been genetically implicated in signal transduction pathways necessary for the establishment of patterning. Sgg is a putative component of the Wingless (Wg) pathway, and epistasis analyses suggest that Sgg function is repressed by Wg signaling. Here, we have investigated the biochemic...

Objective. To assess the incremental costeffectiveness of 3 Pneumocystis carinii pneumonia (PCP) prophylaxis strategies in patients with Wegener’s granulomatosis (WG) receiving immunosuppressive therapies: 1) no prophylaxis; 2) trimethoprim/sulfamethoxazole (TMP/SMX) 160 mg/800 mg 3 times a week, which is discontinued if patients experience an adverse drug reaction (ADR); and 3) TMP/SMX 160 mg/...

climate change is one of the most important factors that will affect different parts of human life on earth and will be adverse effects on environmental resources, economic, social and especially water resources, with changes in rainfall and timing of runoff amount.one of the strategies to mitigate the effects of climate change is to assess its effects on precipitation, temperature and runoff i...

Pseudorandom number generators play an important role to provide security and privacy on radio frequency identification (RFID) tags. In particular, the EPC Class 1 Generation 2 (EPC C1 Gen2) standard uses a pseudorandom number generator in the tag identification protocol. In this paper, we first present a pseudorandom number generator, named the filtering nonlinear feedback shift register using...

In this research, monthly rainfall of Shiraz synoptic station from March 1971 to February 2016 was studied using different time series models by ITSM Software. Results showed that the ARMA (1,12) model based on Hannan-Rissanen method was the best model which fitted to the data. Then, to assess the verification and accuracy of the model, the monthly rainfall for 60 months (from March 2011 to Feb...

The finding that Wingless (WG) and Decapentaplegic (DPP) suppress each others transcription provides a mechanism for creating developmental territories in fields of cells. Here, we address the mechanism of that antagonism. The dishevelled (dsh) and shaggy (sgg) genes encode intracellular proteins generally thought of as downstream of WG signaling. We have investigated the effects of changing ei...