Rat salivary gland epithelial cell cultures were initiated and maintained by the avoidance of trypsin in the early passages. These cells and fibroblasts were treated with 3-methylcholanthrene and 7,12 dimethylbenzanthracene according to estab lished protocols. The epithelial cell lines were remarkably susceptible to the toxicity of the hydrocarbons for their first 15 to 20 passages. After the 2...

The effect of ingestion of dietary oxidized groundnut oil on the histology of wistar rat brain (cerebral cortex), liver, and kidney were examined. Female weanling rats (Rattus norvegicus) were maintained for 12 weeks on intermittently thermoxidzed groundnut oil at 15% dietary level as part of a balanced diet. Fresh (unheated) groundnut oil served as the control. Histological examination of the ...

Ethanol in the presence of disulfiram (N,N,N',N'-tetraethylthiuram disulfide, an inhibitor of aldehyde dehydrogenase) inhibited liver beta-alanine-oxoglutarate aminotransferase (beta-AlaAT I) activity yet activated tyrosine aminotransferase (TAT) in weanling rats in vivo. The effect on beta-AlaAT I was followed by the inhibitory expression of beta-AlaAT I mRNA. The beta-AlaAT I activity was red...

Rat salivary gland epithelial cell cultures were initiated and maintained by the avoidance of trypsin in the early passages. These cells and fibroblasts were treated with 3-methylcholanthrene and 7,12 dimethylbenzanthracene according to estab lished protocols. The epithelial cell lines were remarkably susceptible to the toxicity of the hydrocarbons for their first 15 to 20 passages. After the 2...

The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m(2) body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 weeks by intravenous injection, and the femur, sternum, humerus and tibia were examined histopatholog...

A protein fraction which inhibits growth of weanling rats was obtained from Phaseolus vulgaris seeds of the Sanilac variety by extraction with sodium chloride solution and removal of extraneous materials by precipitation at pH 4.0 and absorption on I : I bentonite-Celite. The protein was precipitated by 0.75 saturation with ammonium sulfate. The growth inhibiting protein fraction contained at l...

Weanling Sprague Dawley rat pups (Rattus norvegicus) selected between 2 safe palatable diets in concordance with the preferences of either an adult or a juvenile conspecific model (Experiment 1). Nevertheless, weanlings chose to feed more in the vicinity of an adult than in the vicinity of a juvenile, thus fulfilling the prediction of an adaptive feeding strategy (Experiment 2). The weanlings' ...