The theoretical framework for dissolution of weak acid and weak base drug compounds in buffered media is well established. Therefore, this article is intended to provide a review of this framework and apply it to formulate buffered dissolution media based on ionic equilibrium conditions within the diffusion layer at the solid–liquid interface. The pHo in the microenvironment is identified as a ...

Intercell interference is a major limiting factor in wireless multi-cell networks. Recently, it has been shown that significant performance gains can be achieved by cooperation between base stations. Different degrees of cooperation are possible: From full cooperation, where multiple base stations form a virtual antenna array, to weak cooperation, where base stations take into consideration the...

Innovation plays an increasingly important role in health care, partly because it is responsible for a significant share of national investment in research and development, and partly because of its industrial and service provision base, which provides a conduit to future technology. The relationship between health care and development is also strengthened as a result of the leading role of hea...

This paper introduces AdaBoost Dynamic, an extension of AdaBoost.M1 algorithm by Freund and Shapire. In this extension we use different “weak” classifiers in subsequent iterations of the algorithm, instead of AdaBoost’s fixed base classifier. The algorithm is tested with various datasets from UCI database, and results show that the algorithm performs equally well as AdaBoost with the best possi...

Value weak hashtables retain only weak references to the values associated with either a strongly or weakly referenced key. Value-weak hashtables automatically remove entries with invalid weak references, which occur when the collector reclaims a weakly referenced value. Value-weak hashtables provide a convenient way to automatically manage a table of information whose entries do not need to ex...

A new air-stable nickel precatalyst for C-N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C-N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive fun...

In this issue of Neuron reveal that weak base antipsychotic drugs inhibit presynaptic function in an activity-dependent manner via their release from synaptic vesicles.

In the title compound, C(51)H(56)B(2)N(2), a substituted Tröger's base, the dihedral angle between the two benzene rings constituting the Tröger's base framework is 104.42 (6)°. The crystal structure is stabilized by C-H⋯π and weak C-H⋯N inter-actions.

Mutation testing is a fault based testing technique in which mutants are generated in the program and apply different test cases on the mutants. Some mutants are killed and some mutants are alive. On the base of killed and alive mutants, mutant score is calculated. Mutants are categorizing into weak, strong and firm mutants on the cost reduction methods. This paper is used to review the mutatio...