Proof of Theorem 4. For wa ∈ [c + ck, rck w−c ], we have the boundary equilibrium. From its definition, yb(ξ) is decreasing in wa (that is, dyb(ξ) dwa < 0) and yb(ξ) = μ + ξ + G−1( r−c−ck r ) when wa = c + ck. The total supply chain profit at the boundary equilibrium is Πtot(yb(ξ), yb(ξ), ξ) = rEmin(μ + ξ + , yb(ξ)) − (c + ck)y(ξ) from Equations (16) and (17). This function is concave and incre...

Cultivation of algae for biofuel would result in the production of significant amounts of post-extraction algal residue (PEAR). The economic viability of algae as source of biofuel is dependent on deriving value from PEAR. Livestock feed is an attractive option for PEAR because of the successful utilization of other co-products by ruminants. While sufficient quantities of PEAR were not availabl...

The 70 C-terminal amino acids of Wiskott-Aldrich syndrome protein (WASp WA) activate the actin nucleation activity of the Arp2/3 complex. WASp WA binds both the Arp2/3 complex and actin monomers, but the mechanism by which it activates the Arp2/3 complex is not known. We characterized the effect of WASp WA on actin polymerization in the absence and presence of the human Arp2/3 complex. WASp WA ...

University of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA University of Washington, Department of Pathology, Seattle, WA 98195 University of Washington, Department of Medicine, Division of Oncology, Seattle, WA 98195 Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA Shanghai Sunway Biotech, No.1150, GuiQiao Road, Pudong, Shanghai 201206,...

BACKGROUND Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA ...

In order to determine the presence and extent of obstructive pulmonary vascular disease in patients with congenital heart disease, magnified cineangiograms were obtained with a catheter in the pulmonary artery wedge position in 155 infants and children undergoing cardiac catheterization. The wedge angiograms (WA) were analyzed in groups according to the pulmonary hemodynamics: group A normal pu...

D. B. Percival, Applied Physics Laboratory, University of Washington, Box 355640, Seattle, WA 98195–5640, USA. ([email protected]) D. A. Rothrock, Applied Physics Laboratory, University of Washington, Box 355640, Seattle, WA 98195–5640, USA. ([email protected]) A. S. Thorndike, Department of Physics, University of Puget Sound, 1500 N. Warner, Tacoma, WA 98416, USA. (thorndike@ups...

1 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 2 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA. 4 Group Health Center for Health Studies, Seattle, WA. 5 Current affiliation: Epidemiol...

Withaferin A (WA) is a bioactive compound derived from a medicinal plant Withania somnifera and has potential therapeutic effects against various types of cancers. The purpose of this study is to investigate an apoptotic effect of WA and identify its molecular target in HSC-3 and HSC-4 human oral cancer cell lines using Trypan blue exclusion assay, DAPI staining and western blotting. WA inhibit...