Traditional Fuzzy Automata are not sufficient to model complex real life applications such as biomedical systems where the inputs can be in terms of Fuzzy. Watson Crick Finite Automaton, which works on Double Stranded tapes was introduced a computational analyze DNA molecule for purpose. The concept Fuzziness and studied theory Automaton. thought an effective computing with problems having inco...

Chemical analysis of metalized DNA has made it quite clear that traditional models thermodynamics are insufficient to predict and control self-assembly in the context orthogonally-paired nucleotides. Recently, there been an increase reports Watson-Crick assembly wires nanostructures [1–4]. The ability add or remove pairing rules between nucleobases toward non-Watson-Crick, orthogonal, alters fu...

The pyr*pur.pyr type of nucleic acid triplex has a purine strand that is Hoogsteen-paired with a parallel pyrimidine strand (pyr*pur pair) and that is Watson-Crick-paired with an antiparallel pyrimidine strand (pur.pyr pair). In most cases, the Watson-Crick pair is more stable than the Hoogsteen pair, although stable formation of DNA Hoogsteen-paired duplexes has been reported. Using oligomer t...

A high affinity RNA aptamer (APT58, 58 nt long) against mammalian initiation factor 4A (eIF4A) requires nearly its entire nucleotide sequence for efficient binding. Since splitting either APT58 or eIF4A into two domains diminishes the affinity for each other, it is suggested that multiple interactions or a global interaction between the two molecules accounts for the high affinity. To understan...

a r t i c l e i n f o a b s t r a c t We study a generalization of the classical notions of bordered and unbordered words, motivated by biomolecular computing. DNA strands can be viewed as finite strings over the alphabet {A, G, C, T}, and are used in biomolecular computing to encode information. Due to the fact that A is Watson–Crick complementary to T and G to C, DNA single strands that are W...

To provide molecular-level insights into the spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β (polβ), we report four crystal structures of polβ complexed with dG•dTTP and dA•dCTP mismatches in the presence of Mg2+ or Mn2+. The Mg(2+)-bound ground-state structures show that the dA•dCTP-Mg2+ complex adopts an 'intermediate' protein conformation wh...

DNA Doplets In article 2200180, Masahiro Takinoue and co-workers show here that droplets, a liquid-state micro-scale self-assembly of sequences empower scientists engineers to ‘program’ their sequence recognition capabilities physical properties by the Watson–Crick base-pairing rule. Here, two types droplets (green blue) are designed favor coalescence with ones same color.

Double helix variations of glycol nucleic acids (GNA) are revealed by the atomic resolution crystal structure of a 6mer GNA duplex containing solely Watson-Crick type hydrogen-bonded base pairs.

We have evaluated the NMR shielding tensors for A:T,G:C,A:U in Watson-crick, and U-quartet. We have computed NMR shielding tensors at B31YP level by using 6-31G(d) basis set. We have compute anisotropy and asymmetry in A:T,G:C,A:U and U-quartet. The NMR shielding tensors were calculated using the GIAO method. The natural bonding orbital analysis (NBO) were performed. NBO calculation have been ...