Interleukin-1 alpha mediates the anti-proliferative effects of 1,25 dihydroxyvitamin D3 in prostate progenitor/stem cells Sophia L. Maund, Wendy W. Barclay, Laura D. Hover, Linara S. Axanova, Guangchao Sui, Jason D. Hipp, James C. Fleet, Andrew Thorburn, and Scott D. Cramer Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157; Wak...

AFFILIATIONS: Altitude Research Center, Dept. of Emergency Medicine, Dept. of OB/Gyn, and Dept. of 6 Health/Behavioral Sciences, University of Colorado Denver, Denver, CO; Instituto Boliviano de Biología de 7 Altura, La Paz, Bolivia, Graduate School of Arts and Sciences, Wake Forest University, Winston-Salem, NC. 8 Anthroplogical Genetics Laboratory, Pennsylvania State University, State College...

The suprachiasmatic nucleus (SCN) is part of a wake-promoting circuit comprising the dorsomedial hypothalamus (DMH) and locus coeruleus (LC). Although widely considered a "master clock," the SCN of adult rats is also sensitive to feedback regarding an animal's behavioral state. Interestingly, in rats at postnatal day (P)2, repeated arousing stimulation does not increase neural activation in the...

In this work we devise a classification of mouse activity patterns based on accelerometer data using Detrended Fluctuation Analysis. We use two characteristic mouse behavioural states as benchmarks in this study: waking in free activity and slowwave sleep (SWS). In both situations we find roughly the same pattern: for short time intervals we observe high correlation in activity--a typical 1/f c...

State of the art turbomachinery flow analysis codes are not capable of predicting the viscous flow features within turbomachinery blade wakes. Until efficient 3D viscous flow analysis codes become a reality there is therefore a need for models which can describe the generation and transport of blade wakes and the mixing process within the wake. To address the need for experimental data to suppo...

background & aim : mother-infant separation is one of the main causes of sleep-wake states disorders in neonatal intensive care unit (nicu). the current study was conducted to investigate the effect of in-arms-holding by mothers on sleep-wake states disorders of preterm neonates. methods & materials : in a pilot study, through a semi-experimental pretest-posttest method, 35 preterm neonates wit...

 ABSTRACT Background: The efficacy of anticonvulsants after a first seizure is uncertain the more predictable the time and the type of recunent seizure, the more preventable the probable events. This study was conducted to evaluate sirnilmity of type and time of a first seizure and its recutTence in children. Methods: 174 children with at least two separate seizures were taken into account. Res...

The locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus noradrenergic neurons has long-suggested a role of this system in the induction of an alert waking state. Work over the past two decades provides unambiguous evidence that the locus coeruleus, and likely other noradrenergic nuclei...

Potential flow solvers for 3D aerodynamic flows are commonly used in industrial applications. Two main difficulties preventing the even more widespread use of these codes are the limitations on the number of discretization elements and the user expertise and effort required to specify the wake location. In the paper we present an automatic wake generation strategy for a potential flow solver, a...

An extensive experimental study is conducted to examine effects of different winglet-shapes and orientations on the vortex behind a wing, static surface pressure over the wing, and wing wake of a swept wing at various angles of attack. Four types of winglets, spiroid (forward and aft), blended, and winggrid are used in this investigation. Wing static surface pressure measurements are obtained f...