Fingolimod (FTY720), a sphingosine-1-phosphate receptor (S1PR) modulator, was the first oral therapy approved by US Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of relapsing-remitting multiple sclerosis[1]. To date, fingolimod has not been studied in epilepsy models; however, a recent study performed in the lithium-pilocarpine rat model of SE (status ...

Abstract Enhancing oil recovery in reservoirs with light and high gas content relies on optimizing the miscible water alternating (WAG) injection profile. However, this can be costly time-consuming due to computationally demanding compositional simulation models numerous other well control variables. This study introduces WAG eq , a novel approach that expedites convergence of optimization algo...

Water alternating gas (WAG) flooding is a widely employed enhanced oil recovery method in various reservoirs worldwide. In this research, we will employ SiO2 nanofluid with the CO2 injection as replacement for conventional WAG process experiments. The suffers from limitations certain industrial applications, such extended cycle times, susceptibility to water condensation and agglomeration, inef...

several studies have shown that oil recovery significantly increased by low salinity water flooding (lswf) in sandstones. however, mechanism of oil recovery improvement is still controversial. co2 that develops buffer in presence of water is expected as a deterrent factor in lswf efficiency based on mechanism of ift reduction due to ph uprising. no bright evidence in literature supports this id...

The most common type of childhood-onset epilepsy syndrome is childhood absence epilepsy (CAE) with well-defined electro clinical features but unknown pathological basis. The incidence of absence epilepsy is about 2 and 8 out of every 100 000 children up to the age of 16, and the prevalence is 2 and 10% of children with any form of epilepsy. Children with CAE suffer from high rate of pretreatmen...

UNLABELLED Ovarian hormones play an important role in the regulation of absence seizures in patients as well as in animal models. The present study examined whether chronic progesterone exposure would induce tolerance for the occurrence of absence seizures and whether reduction in gonadal steroids (via ovariectomy) would alter the number of basal and stress induced absence seizures in WAG/Rij r...

reduces rotational mobility of the CD. Upon release of P i from the active site, actomyosin affinity increases and stress is applied to the LC domain. A fulcrum (probably near residue Cys-707, Figure 1) translates this stress into rotation of the neck toward the barbed end of the University of Pennsylvania actin filament (downward in Figures 1 and 2) transmitting Philadelphia, Pennsylvania 1910...