BACKGROUND Epidemiological studies that used birthweight as a crude marker of fetal growth have suggested that low birthweight is associated with increased risk of coronary heart disease. Through investigation of this association within same-sexed twin pairs, confounding by genetic and early environmental factors can be greatly decreased. We undertook a case-control study in twins discordant fo...

The Beginnings The seeds of the project began to germinate in late 1990 and early 1991 with our effort to rapidly prototype large-scale shared-memory multiprocessors. Because other research groups had a oneto two-year lead in their prototyping efforts—and considerably more resources—our project started with the goal of exploiting the parallel computers that our department was acquiring with fun...

Gibbsite both invests and replaces crocoite in late supergene ores of the Dundas district, Tasmania. The laser Raman spectrum of the gibbsite shows strong, well-developed v-OH stretching bands at about 3370, 3440, 3525, 3620 cm-I, confirming its identity. Crocoite gives bands at 840 em-Iv!, 853 and 825 cm-l v3, 348 cm-l v 2, 400, 377, 358, 338 and 326 cm-l v 4, and at 179,135, and 118 em-I, cor...

OBJECTIVE To localize susceptibility genes for alterations in brain structure associated with risk of stroke and dementia. We conducted genomewide linkage analyses for magnetic resonance imaging (MRI) measures of brain atrophy, ventricular, and subcortical white matter hyperintensity (leukoaraiosis) in 689 non-Hispanic white (673 sibling pairs; median age, 61 years) and 544 non-Hispanic black p...

BACKGROUND Causative treatment of patients with wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) is lacking. Recent reports indicate the potential use of epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, to inhibit amyloid fibril formation. We sought to investigate changes of cardiac function and morphology in patients with wtATTR-CM after consumption of gree...