Breast like carcinomas of the vulva was thought to be originated from ectopic breast tissue or metastasis from breast. It is now accepted that, as mammary-like glands are present in the vulva, any pathology that is found in the breast can be seen at these glands. Adenocarcinoma of the vulva is rare and the breast-like adenocarcinomas are presented as case reports in the literature. We present a...

We here report the case of a 58-year old female patient with no particular past medical history, presenting with a 5-year history of vulvar pruritis, drought and vulvodynia at the Department of Dermatology. Clinical examination showed diffuse porcelaine lesions at the level of the vulva, with a yellowish hemispheric nodular lesion measuring 1 cm in diameter on the whitish plates and some excori...

Dear Editor, We revised our paper entitled " Early invasive vulvar squamous cell carcinoma arising in a women with vulvar pemphigus vulgaris and systemic lupus erythematosus" according to Editor’s suggestions. Author list: the list of authors in the manuscript was written exactly as it is in the submission system, both in style and order. The preferred style was followed Authors' contributions:...

Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squa...

Mammary-like adenocarcinoma of the vulva associated to Paget's disease is exceedingly rare. So, it is very important to perform all the pathological and immunohistochemical investigations to achieve differential diagnosis from both a metastatic lesion from an orthotopic breast cancer and a vulvar adnexal tumor. This report describes a case of vulvar Paget's disease associated with underlying ma...

OBJECTIVE This study attempted to examine the methylation status of SH3GL2 gene in different types of human vulvar lesions and its correlation with clinicopathological parameters. METHODS Immunohistochemical analysis was used to identify the expression status of SH3GL2 in vulvar squamous cell carcinoma (VSCC), vulvar intraepithelial neoplasia (VIN) and benign vulvar squamous epithelium tissue...

BACKGROUND Treatment of recurrent gynecologic cancer is a challenging issue. Aim of the study was to investigate clinical features and outcomes of patients with recurrent gynecologic malignancies who underwent resection including IOERT (intraoperative electron radiation therapy) with regard to clinical outcome and potential predictive factors or subgroups that benefit most from this radical tre...

Unregulated expression of microRNAs is well known and has already been demonstrated in many tumor types. However, in vulvar carcinoma this field has been unknown territory. Our study characterizes microRNA in vulvar tumors through an expression profile of 754 miRNAs, relating this with clinical and anatomopathologic data, and presence of HPV infection. Twenty HPV-negative and 20 HPV-positive sa...