The aim of the present study was to evaluate serum concentrations of vascular endothelial growth factor (VEGF) in patients with vulvar cancer and healthy female controls with respect to correlation of VEGF with clinicopathological parameters and impact on the patients' prognosis. Serum concentrations of VEGF were measured using a commercially available ELISA. Results were correlated to clinical...

BACKGROUND The association between lichen sclerosus and vulvar squamous cell carcinoma (VSCC) has long been recognized, but large epidemiologic studies are lacking. METHODS Data of women diagnosed with vulvar pathology in the Netherlands were retrieved from the Dutch Pathology Registry. All vulvar pathology reports of this historical cohort were reviewed to construct a research database, incl...

Vulvar cancer (VC) represents about 4% of gynecologic malignancies, its incidence increases with age and peak incidence is found between 70-79 years. In cases of locally advanced disease surgery is often required and radical vulvectomy, with or without mono-bilateral inguino-femoral lymphadenectomy, is standard management. Various devices have been implemented in gynecological surgery in an att...

CONTEXT AND OBJECTIVE Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. DESIGN AND SETTING Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. METHODS Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics...

Vulvar cancer is rare with incidence of 45,240 new cases globally which account for 4% all genitourinary tract neoplasma. It considered as a postmenopausal disease, however age has decreased over the years because high prevalence persistent high-risk human papillomavirus (hrHPV) infection. diagnosis in young women challenging. Prompt and adequate diagnosis, treatment can ensure life quality. A ...

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gastroesophageal-vul var leiomyomatosis is a very rare condition it is characterized by diffuse, ill-defined proliferation of smooth muscle in the esophagus and vulva. we present an interesting case of esophageal leiomyomatosis in a woman with a history of vulvar leiomyomatosis and a gall bladder full of stones. she was 18-years old and had a 4 year history of vulvar mass and clitoromegaly, wit...