نتایج جستجو برای: vivo permeation

تعداد نتایج: 339759  

2017
Boonnada Pamornpathomkul Adisak Wongkajornsilp Wanida Laiwattanapaisal Theerasak Rojanarata Praneet Opanasopit Tanasait Ngawhirunpat

The aim of this study was to investigate the use of different types of microneedles (MNs) and nanocarriers for in vitro skin permeation and in vivo immunization of plasmid DNA encoding ovalbumin (pOVA). In vitro skin permeation studies indicated that hollow MNs had a superior enhancing effect on skin permeation compared with solid MN patches, electroporation (EP) patches, the combination of MN ...

Journal: :Journal of Drug Delivery Science and Technology 2022

The aim of this research was to investigate the effect non-invasive dermal electroporation (EP) on barrier function skin and permeation a model macromolecule in combination with different formulations. Skin samples were treated EP treatment for 2 min. Firstly, examined mouse vivo by measuring transepidermal water loss (TEWL). Then, human investigated ex under fluorescence microscope solution, h...

2017
Peijun You Ran Yuan Chuanyu Chen

PURPOSE Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS In this study, for combination anesthesia and over...

2016
Hamdy Abdelkader Michael R Longman Raid G Alany Barbara Pierscionek

This study reports on L-carnosine phytosomes as an alternative for the prodrug N-acetyl-L-carnosine as a novel delivery system to the lens. L-carnosine was loaded into lipid-based phytosomes and hyaluronic acid (HA)-dispersed phytosomes. L-carnosine-phospholipid complexes (PC) of different molar ratios, 1:1 and 1:2, were prepared by the solvent evaporation method. These complexes were character...

2012
Yan Chen Lei Zhou Ling Yuan Zhen-hai Zhang Xuan Liu Qingqing Wu

BACKGROUND Nanostructured lipid carriers (NLCs) are attractive materials for topical drug delivery, and in a previous study, we demonstrated that NLCs loaded with tripterine enhance its deposition. However, the surface charge of nanoparticles influences percutaneous drug penetration. Therefore, we aimed to evaluate the influence of the surface charge of NLCs on in vitro skin permeation and in v...

Journal: :Journal of Pharmaceutical Investigation 2023

Abstract Purpose Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of present study was apply this solubility enhancement technique a poorly soluble delivery, comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, correspo...

2016
Mohamed A El-Nabarawi Adel A Ali Heba M Aboud Amira H Hassan Amany H Godah

OBJECTIVE Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière's disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. The aim of the present work was to develop and estimate controlled release mucoadhesive buccal tablets of BH.2HCl with a unidirectional drug flow to overcome this encumbrance. METHOD...

Journal: :iranian journal of pharmaceutical research 0
maryam kouchak a nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran b department of pharmaceutics, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran reza bahmandar nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran neda bavarsad a nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran b department of pharmaceutics, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran fereydoun farrahi department of ophthalmology, imam khomeini hospital, ahvaz jundishapur university of medical sciences, ahvaz, iran

dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. the aim of this study is to develop ocular dorzolamide hcl nanoliposomes (drz – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. nanoliposomes were prepared using reverse-phase evaporation vesicle (rev) and thin layer hydration (tlh...

Journal: :Current Medicinal Chemistry 2021

The development of biodegradable nanoparticles is an important tool for the biological transport chemical compounds. nanoencapsulation reduces biopharmaceutical and pharmacokinetic drawbacks compounds enhances their properties. Naturally occurring polymers such as proteins polysaccharides have been widely applied in nanostructured systems several therapeutic agents. Among them chitosan, a crust...

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