WHAT IS KNOWN AND OBJECTIVE Based on in vitro assays and select animal models, buprenorphine is commonly called a 'partial agonist'. An implication is that it should produce less analgesic effect in humans than so-called 'full agonists' such as morphine or fentanyl. However, buprenorphine has a multimechanistic pharmacology, and thus partial agonism at a specific receptor is not particularly re...

BACKGROUND/AIM Hypoxia can affect chemotherapeutic drug efficacy in cancer patients, yet related in vitro assays in oxygen-rich environment remain the norm. Such levels are well beyond normoxic/hypoxic levels typically experienced by normal tissues/tumor masses. The present study evaluated how artesunate anti-tumor efficacy is modulated by oxygen availability in HeLa cells and its implications ...

non-steroidal anti-inflammatory drugs (nsaids), including selective cyclooxygenase (cox)-2 inhibitors, have come to play an important role in the pharmacologic management of musculoskeletal disorders. clinical trials have established the efficacy of etoricoxib in osteoarthritis, rheumatoid arthritis, acute gouty arthritis, ankylosing spondylitis, low back pain, acute postoperative pain, and pri...

this research was conducted to evaluate the effects of electron beam (eb) and gamma ray (gr) radiations at doses of 25, 50 and 75 kgy on ruminal degradation kinetics of dry matter (dm) and crude protein (cp),andin vitro digestibility of canola meal (cm). the nylon bag technique and in vitro two step method were used for this aim. gr decreased ruminal degradability of dm (p<0.05), but eb had no ...

objective(s): the aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (slns) containing zataria multiflora essential oil (zeo). materials and methods: in this study, z. multiflora essential oil-loaded solid lipid nanoparticles (ze-slns) were prepared to improve its efficiency in controlling some fungal pathogens. slns containing z. multiflora essential ...

Free fatty acids (FFAs) and acid synthesis (FAS) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, several types of cancer. Currently, treatment options are available for patients with these conditions. Due safety concerns, adverse effects, limited efficacy, low tolerability associated many medi...

Objective(s): The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). Materials and Methods: In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in controlling some fungal pathogens. SLNs containing Z. multiflora essential ...

crimean-congo hemorrhagic fever is a tick-borne viral disease reported from more than 30 countries in africa, asia, south-east europe, and the middle east. the majority of human cases are workers in livestock industry, agriculture, slaughterhouses, and veterinary practice. the current mortality rate in endemic areas varies between 5 to 20 percent depending on the geographic location and medical...

Background and objectives: Benzimidazoles such as albendazole are being used in some conditions to treat the hydatid disease, the common parasitic infections of humans and livestock that caused by Echinococcus granulosus. However, treatment with these drugs is not always with complete success. In this study we evaluate the in vitro efficacy of flubendazole (FLBZ) plus praziquantel (PZQ) against...