INTRODUCTION The course and prognosis of vitreous hemorrhage (VH) are difficult to predict in spite of so far published experimental and clinical studies. OBJECTIVE The goal of this study was to follow the course and evaluate prognosis of vitreous hemorrhage. METHODS The experiment was performed on 19 Chinchilla rabbits (Oryctolagus cuniculus), both males and females (38 eyes), weighing 250...

AIM To examine the outcome of a triamcinolone acetonide (TA) assisted pars plana vitrectomy (PPV) for refractory uveitis. METHODS Six patients suffering from proliferative vitreoretinopathy (PVR) with refractory uveitis underwent a TA assisted PPV. The patients consisted of one with Vogt-Koyanagi-Harada disease, one with acute retinal necrosis, one with Behçet's disease, and three with sarcoi...

Using radioimmunoassay techniques, we measured the amounts of prostaglandin E (PGE) in the aqueous humor and vitreous body of 22 phakic and ten aphakic rabbit eyes. Either epinephrine and placebo, epinephrine and indomethacin, indomethacin and placebo, or placebo and placebo were administered topically for 5 months. Treatment of aphakic eyes was initiated 1 month after intracapsular lens extrac...

The vitreous body has become an interesting location for the administration of injections or implants in modern ophthalmology. Such intravitreal dosage forms are loaded with active agents which are released over a prolonged period of time. A test method simulating the in vivo situation is needed to observe the release behaviour of these new dosage forms and the distribution of drug substances i...

PURPOSE To evaluate morphologic aspects of age-related liquefaction of the human vitreous body by light and electron microscopy to provide a basis from which future studies directed at the pathogenesis of this phenomenon can be undertaken. The study focuses on changes in fibrillar collagen and proteoglycans (PGs). METHODS Morphologic aspects of intravitreal liquefied spaces and matrix areas s...

One of the outstanding problems in ophthalmology to-day is the elucidation of etiological factors in the primary glaucomas, i.e., those not directly resulting from obvious pathological or anatomical defects of the eye. Our knowledge of the mechanisms productive of intraocular hypertension in such cases has been greatly augmented in recent years by the publications of Duke-Elder, Seidel, Magitot...

PURPOSE To evaluate levels of malondialdehyde and the total antioxidant capacity (TAC) in the blood, aqueous humor, and vitreous bodies of diabetic and nondiabetic patients. We also measured the blood energy charge potential (ECP). METHODS We examined 19 patients with type 2 diabetes mellitus and diabetic retinopathy. Ten were scheduled for cataract surgery and pars plana vitrectomy because o...

PURPOSE To investigate the precipitation process of a mixture of vancomycin and ceftazidime by equilibrium dialysis and determine its subsequent effect on the level of free antibiotics for treatment of endophthalmitis. METHODS Concentrations of vancomycin and ceftazidime in an equilibrium dialysis chamber were measured during the equilibrium process by high-performance liquid chromatography. ...

PURPOSE Preliminary assessment of a new prototype ultrasound-based hypersonic vitrector (HV) by qualitatively examining the histopathological changes in the retina and vitreous body after pars plana vitrectomy (PPV) and its ability to fragment vitreous collagen. METHODS Fourteen porcine cadaveric eyes, 20 eyes in live swine and six human cadaveric eyes underwent PPV using the HV or a pneumati...

Aim: To examine the outcome of a triamcinolone acetonide (TA) assisted pars plana vitrectomy (PPV) for refractory uveitis. Methods: Six patients suffering from proliferative vitreoretinopathy (PVR) with refractory uveitis underwent a TA assisted PPV. The patients consisted of one with Vogt-Koyanagi-Harada disease, one with acute retinal necrosis, one with Behçet’s disease, and three with sarcoi...