multiple risk factors are introduced for multiple sclerosis (ms). recent studies have suggested a possible correlation between vitamin d deficiency and an increase risk of ms. this study was therefore undertaken to compare vitamin d levels in new cases of ms and their relatives as healthy controls. seventy five new diagnosed ms patients and 100 matched healthy controls among their relatives wer...

1. Mankertz A, Mihneva Z, Gold H, Baumgarte S, Baillot A, Helble R, et al. Spread of measles virus D4-Hamburg, Europe, 2008–2011. Emerg Infect Dis. 2011;17:1396–401. 2. Muscat M. Who gets measles in Europe? J Infect Dis. 2011;204(Suppl 1):S353–65. http://dx.doi.org/10.1093/infdis/jir067 3. Centers for Disease Control and Prevention. Increased transmission and outbreaks of measles—European Regio...

Progressive multifocal leukoencephalopathy (PML) is a progressive lethal demyelinating disease of the brain, caused by JC virus. Reactivation of JC virus due to reduction of cellular immunity especially in setting of AIDS, is the commonest underlying cause. PML has classically been described in individuals with profound cellular immunosuppression such as patients with AIDS, haematological malig...

Leptin, an adipocyte-derived hormone, plays crucial roles in the regulation of energy expenditure and food intake. Through analyses of leptin transgenic mice, we have demonstrated that leptin has pleiotropic effects such as regulation of insulin sensitivity and lipid metabolism. Lipodystrophy is a disease characterized by a lack of adipose tissue, which leads to metabolic disorders including in...

Background: Due to the interruption of the EHC pathway in NAFLD patients, we hypothesized that parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with NAFLD. Therefore, this study aimed to compare the efficacy of oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with NAFLD. Methods: In this prospective ...

We thank Dr Aelony for his interest in our recent article in CHEST (June 2010) 1 on the occurrence of lung injury following thoracoscopic talc insuffl ation (TTI). We did not report on pleurodesis success rate because our goal was to determine the incidence of respiratory complications. We acknowledge the design limitations of our retrospective study. We carefully assessed all cases of postproc...

OBJECTIVE In this study, we aimed to compare the effect(s) of zinc sulphate on growth and serum iron variables when it is given with ferrous sulphate in iron deficiency anemia (IDA). MATERIALS AND METHODS Patients (n=79) were randomly divided into two groups. In one group (n=40) 4 mg/kg/d ferrous sulfate was given orally. In the other group (n=39), in addition to ferrous sulfate, 5 mg/d oral ...

Author’s Affi liation: The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts Corresponding Author: Michael T. Hemann, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 76-361B, Cambridge, MA 02139. Phone: 617324-1964; Fax: 617-252-1891; E-mail: hemann...