Since the isolation of crystalline vitamin B12 (B12) from liver many reports have appeared during the past several years on the supplemental effect of the vitamin on the growth of children in U.S.A. and in some other countries (1). The duration of the studies was from 4 weeks to 2 years, and the number of children subjected to individual study was from 9 to 418. The status of the subjects in ea...

Increasing concentrations of vitamin B 12 were fed to 144 weanling pigs (weaned 13-14 days) in two, five-week trials.­ Pigs were fed one of six diets: NC, negative control, basal diet without supplemented vitamin B 12 ; or the basal diet with the inclusion of 100% (1X, 7.­94 μg/lb), 200% (2X, 15.­87 μg/lb), 400% (4X, 1.­75 μg/lb), 800% (8X, 6.­49 μg/lb), or 1,600% (16X, 126.­98 μg/lb) of NRC re...

J-'He occasional development of cerebral ^citation and other forms of psychoses in ^larial subjects treated with atebrin is the experience of many, and in the past was^ reported several times by various workers including ^ngsbury (1934), Udalagama (1935) and Hay ol. (1935). The exact mechanism of its Production is not yet known. Recently the ^riter came across four such cases of mental derangem...

A simple, rapid ultrafiltration technique has been used to separate free vitamin B12 from that attached to the binding factor present in the media of cultures of the marine microalgae Mantoniella squamata and Pavlova lutheri (auxotrophic spec~es) , and Dunaliella primolecta and Phaeodactylum tricomuturn (species with no B12 requirement). The dissociation constant (K,) for the B12-binder complex...

A third vitamin B(12) binding protein present in normal serum has been shown to participate in transport of labelled vitamin B(12) absorbed from the gut. All three vitamin B(12) binding proteins in serum were labelled at the same time after oral administration of vitamin B(12), implying that "free" vitamin B(12) reached the portal blood from the gut mucosa.

Imerslund-Gräsbeck syndrome (IGS) or selective vitamin B(12) (cobalamin) malabsorption with proteinuria is a rare autosomal recessive disorder characterized by vitamin B(12) deficiency commonly resulting in megaloblastic anemia, which is responsive to parenteral vitamin B(12) therapy and appears in childhood. Other manifestations include failure to thrive and grow, infections and neurological d...

The response to small doses of vitamin B10 was studied in a woman with pernicious anemia and thyrotoxicosis. No response to 1 g. per day occurred, but she did respond to 10 1sg. per day. Fourteen months later when she was euthyroid, the patient did respond to 1 g. per day. In another study, serum vitamin B12 levels were significantly lower in a group of patients with hyperthyroidism than in a g...