Adaptation of visually guided reaching movements in novel visuomotor environments (e.g. wearing prism goggles) comprises not only motor adaptation but also substantial sensory adaptation, corresponding to shifts in the perceived spatial location of visual and proprioceptive cues. Previous computational models of the sensory component of visuomotor adaptation have assumed that it is driven purel...

The primate cortex represents and produces events in a distributed way, which calls for a mechanism that integrates their features into coherent structures. Visuomotor integration seems to be driven by dopaminergic (DA) pathways but which subsystems are involved is currently unknown. The present study compared the impact of the recreational use of two drugs on visuomotor integration: cannabis, ...

We examined the psychometric properties (internal consistency, concurrent criterion validity, and known-group validity) of the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) in people with intellectual disabilities. A total of 111 people with intellectual disabilities and 19 people with no disabilities were included. We used Cronbach's alpha, Spearman's rho, the Kruskal-Wallis te...

The effectiveness of a graded series of craft activities on improving visuomotor skills was tested with an inpatient child psychiatry population. A standardized test of visuomotor integration served as a pretest and posttest to compare two nonconcurrent groups in the same setting. The inpatient program was the same for both groups, except that the treatment group (n = 33) participated in a grad...

The primate cortex represents perceived and produced events in a distributed way, which calls for a mechanism that integrates their features into coherent structures. Animal, drug, and patient studies suggest that the local binding of visual features is under muscarinic-cholinergic control, whereas visuomotor binding seems to be driven by dopaminergic pathways. Consistent with this picture, we ...

|The basal ganglia (BG) have been hypothesized to perform reinforcement learning by use of reinforcement signals provided by dopamine neurons. It is well known that there exist multiple BG-thalamocortical loops, but their functions are poorly understood. Here, we propose a computational model of how di erent BG loops are employed in visuomotor sequence learning using di erent representations of...

The beneficial effect of sleep on motor memory consolidation is well known for motor sequence memory, but remains unsettled for visuomotor adaptation in humans. The aim of this study was to characterize more clearly the influence of sleep on consolidation of visuomotor adaptation using a between-subjects functional magnetic resonance imaging (fMRI) design contrasting sleep to total sleep depriv...

To identify subdivisions of the human parietal cortex, we collected fMRI data while ten subjects performed six tasks: grasping, pointing, saccades, attention, calculation, and phoneme detection. Examination of task intersections revealed a systematic anterior-to-posterior organization of activations associated with grasping only, grasping and pointing, all visuomotor tasks, attention and saccad...

Research has illustrated dissociations between "cognitive" and "action" systems, suggesting that different representations may underlie phenomenal experience and visuomotor behavior. However, these systems also interact. The present studies show a necessary interaction when semantic processing of an object is required for an appropriate action. Experiment 1 demonstrated that a semantic task int...