Numerous applications of nanotechnology have been developed to probe the unique mechanical properties of cells. In addition, since biological materials exhibit such a wide spectrum of properties, they offer new concepts for nonbiological biomimetic applications. In this chapter, the viscoelastic properties of a cell and its subcellular compartments are described. First, a qualitative picture is...

Polysialic acid (polySia) is an important carbohydrate bio-polymer that is commonly over-expressed on tumours of neuroendocrine origin and plays a key role in tumour progression. polySia exclusively decorates the neural cell adhesion molecule (NCAM) on tumour cell membranes, modulating cell-cell interactions, motility and invasion. In this preliminary study, we examine the nano-mechanical prope...

We investigate the question of stability of a solid thin film which experiences external interactions such as van der Waals forces from a contacting surface or forces from an external electric field. Both perfectly elastic and viscoelastic material behaviours are considered in linear stability analysis performed here. These analyses indicate that for sufficiently soft (shear modulus between 1 a...

Nanoindentation is used to determine the dynamic viscoelastic properties of six polymer materials. It is shown that varying the harmonic frequency of the nanoindentation does not have any significant effect on the measured storage and loss moduli of the polymers. Agreement is found between these results and data from DMA testing of the same materials. Varying the harmonic amplitude of the nanoi...

Fouling properties of new biomaterials are important for the performance of a material in a biological environment. Here, a set of three supramolecular polymeric additives consisting of ureidopyrimidinone (UPy)-functionalized poly(ethylene glycol) (UPyPEG) were formulated with UPy-modified polycaprolactone into thin supramolecular material films. The antifouling properties of these material fil...

Hydrogels from self-assembling ionic complementary peptides have been receiving a lot of interest from the scientific community as mimetic of the extracellular matrix that can offer three-dimensional supports for cell growth or can become vehicles for the delivery of stem cells, drugs or bioactive proteins. In order to develop a 3D "architecture" for mesenchymal stem cells, we propose the intro...

Casemaker caddisfly (Hesperophylax occidentalis) larvae use adhesive silk fibres to construct protective shelters under water. The silk comprises a distinct peripheral coating on a viscoelastic fibre core. Caddisworm silk peroxinectin (csPxt), a haem-peroxidase, was shown to be glycosylated by lectin affinity chromatography and tandem mass spectrometry. Using high-resolution H2O2 and peroxidase...

We extend the study [1] devoted to the dynamic response of a structure made of two linearly elastic bodies connected by a thin soft adhesive layer made of a Kelvin Voigt type nonlinear viscoelastic material to the case of a Generalized Standard Material with a positive definite quadratic density of free energy. A concise formulation in terms of an evolution equation in a Hilbert space of possib...

The modelling of the adherence energy during peeling of Pressure Sensitive Adhesives (PSA) has received much attention since the 1950's, uncovering several factors that aim at explaining their high adherence on most substrates, such as the softness and strong viscoelastic behaviour of the adhesive, the low thickness of the adhesive layer and its confinement by a rigid backing. The more recent i...